Correlation of iris collagen and in-vivo anterior segment structures in patients in different stages of chronic primary angle-closure in both eyes
Correlation of iris collagen and in-vivo anterior segment structures in patients in different stages of chronic primary angle-closure in both eyes
复制标题
慢性原发性闭角不同阶段患者虹膜胶原与体内眼前节结构的相关性
DOI：
10.4103/ijo.ijo_1406_18
复制
发表时间：
2019-10-01
影响因子：
3.1
通讯作者：
Huang, Jingjing
中科院分区：
文献类型：
--
作者：
Chung, Chuchen;Dai, Miaomiao;Huang, Jingjing
目的：比较慢性原发性闭角型青光眼 (CPACG) 眼和确诊或疑似原发性闭角型青光眼 (PAC/PACS) 眼的虹膜胶原密度和眼前节参数。方法：招募了 19 名一只眼患有 CPCG，另一只眼患有 PAC/PACS 的患者，需要进行 CPCG 眼小梁切除术和另一只眼虹膜切除术。眼前段光学相干断层扫描（AS-OCT）测量在光照和黑暗条件下进行。通过虹膜切除术/小梁切除术获得的虹膜标本通过天狼星红偏振进行分析，以量化 I/III 型胶原密度。比较两只眼睛的 AS-OCT 参数和 I/III 型胶原密度。结果：CPACG眼在明暗条件下虹膜曲率均较平坦（P < 0.05）。 CPACG眼在光照条件下虹膜面积和黑暗条件下虹膜厚度较小（P < 0.05）。 CPCG眼中I型胶原蛋白的密度较低（P = 0.048）。 CPCG眼和PAC/PACS眼的瞳孔直径明暗变化分别为-0.679±0.701和-1.627±0.802 mm，虹膜面积分别为0.069±0.113和0.258±0.157 mm2，差异显着（P < 0.001）。随着I型胶原蛋白的减少，黑暗条件下前房宽度增加，虹膜面积减少。结论：CPCG 眼与 PAC/PACS 眼的瞳孔直径和虹膜面积动态变化存在显着差异。虹膜组织中 I 型胶原密度的降低与虹膜面积的减小和前房宽度的增加有关，这可能会导致疾病进展。
Purpose: To compare the density of iris collagen and anterior segment parameters in eyes with chronic primary angle closure glaucoma (CPACG) and their fellow eyes with confirmed or suspected primary angle closure (PAC/PACS). Methods: Nineteen patients with CPACG in one eye and PAC/PACS in the fellow eye requiring trabeculectomy in the CPACG eye and iridectomy in the fellow eye were recruited. Anterior segment optical coherence tomography (AS-OCT) measurements were conducted under light and dark conditions. Iris specimens, obtained by iridectomy/trabeculectomy, were analyzed by sirius red polarization for quantifying type I/III collagen density. AS-OCT parameters and type I/III collagen densities were compared between the two eyes. Results: The iris curvatures were flatter in CPACG eyes in light and dark conditions (P < 0.05). The iris areas in light condition and iris thicknesses in dark condition were smaller in CPACG eyes (P < 0.05). The density of collagen type I in CPACG eyes was lower (P = 0.048). The light-to-dark changes in CPACG eyes and PAC/PACS eyes, respectively, were −0.679 ± 0.701 and −1.627 ± 0.802 mm for pupil diameters, and 0.069 ± 0.113 and 0.258 ± 0.157 mm2 for iris areas, which differed significantly (P < 0.001). With the decrease of type I collagen, anterior chamber width increased and iris areas decreased in dark condition. Conclusion: Dynamic changes in pupil diameter and iris areas differed significantly between CPACG eyes and their fellow PAC/PACS eyes. Decreased type I collagen density in iris tissue was associated with decreased iris area and increased anterior chamber width, which may contribute to disease progression.