Quantification of temporal changes in calcium score in active atherosclerotic plaque in major vessels by 18F-sodium fluoride PET/CT
Quantification of temporal changes in calcium score in active atherosclerotic plaque in major vessels by 18F-sodium fluoride PET/CT
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DOI：
10.1007/s00259-017-3680-x
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发表时间：
2017-08-01
影响因子：
9.1
通讯作者：
Inoue, Tomio
中科院分区：
文献类型：
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作者：
Ishiwata, Yoshinobu;Kaneta, Tomohiro;Inoue, Tomio
目的我们的目的是评估F-18-NaF PET/CT是否能够预测CT钙评分的进展。（18名女性，16名男性;年龄，平均值+/-标准差，57.5 +/-13.9岁;年龄范围19 - 78岁）的恶性肿瘤或骨科疾病患者入组本研究，并有大约1年的随访数据。对基线和随访CT图像进行回顾性评价，以确定主要血管壁中是否存在钙化部位。评价每个部位的最大和平均CT值（CTmax和CT mean，Hounsfield单位）、钙化体积评分（CVS，立方毫米）和Agatston单位评分（Au）。计算CTmax、CTmean、CVS和Au的后续变化，并分别表示为Delta CTmax、Delta CTmean、Delta CVS和Delta Au。然后，我们评估了F-18-NaF摄取与（使用最大目标与背景比TBRmax和最大血液扣除F-18-NaF活性bsNaFmax，其通过从右心房血池中的SUV平均值中减去每个钙化斑块病变和NaF亲合位点的SUV最大值获得）结果共检出并分析了182个钙化斑块和96个主要血管壁热点。在每个研究中心的基线和随访PET/CT扫描中，F-18-NaF摄取与CTmax、CTmean、CVS、1年后CVS、Au和1年后Au的相关性非常弱。F-18-NaF摄取与Δ CTmax或Δ CTmean无关。F-18-NaF摄取强度与Delta CVS和Delta Au相关。结论F-18-NaF摄取与钙积分进展密切相关，可作为未来心血管疾病风险的预测指标。使用F-18-NaF的PET/CT可能能够预测钙评分进展，这是动脉粥样硬化的主要特征。
Purpose Our aim was to assess whether F-18-NaF PET/CT is able to predict progression of the CT calcium score.Methods Between August 2007 and November 2015, 34 patients (18 women, 16 men; age, mean +/- standard deviation, 57.5 +/- 13.9 years; age range 19-78 years) with malignancy or orthopaedic disease were enrolled in this study, with approximately 1-year follow-up data. Baseline and follow-up CT images were retrospectively evaluated for the presence of calcification sites in major vessel walls. The maximum and mean CT values (CTmax and CTmean, in Hounsfield units), calcification volumetric score (CVS, in cubic millimetres) and Agatston units score (AU) were evaluated for each site. Subsequent changes in CTmax, CTmean, CVS and AU were calculated and expressed as Delta CTmax,Delta CTmean,Delta CVS and Delta AU, respectively. We then evaluated the relationship between F-18-NaF uptake (using the maximum target-to-background ratio, TBRmax, and the maximum blood-subtracted F-18-NaF activity, bsNaFmax, which was obtained by subtracting the SUVmax of each calcified plaque lesion and NaF-avid site from the SUVmean in the right atrium blood pool) and the change in calcified plaque volume and characteristics obtained after 1 year.Results We detected and analysed 182 calcified plaque sites and 96 hot spots on major vessel walls. F-18-NaF uptake showed very weak correlations with CTmax, CTmean, CVS, CVS after 1 year, AU and AU after 1 year on both baseline and follow-up PET/CT scans for each site. F-18-NaF uptake showed no correlation with Delta CTmax or Delta CTmean. However, there was a significant correlation between the intensity of F-18-NaF uptake and Delta CVS and Delta AU.Conclusion F-18-NaF uptake has a strong correlation with calcium score progression which was a predictor of future cardiovascular disease risk. PET/CT using F-18-NaF may be able to predict calcium score progression which is known to be the major characteristic of atherosclerosis.