Primary cutaneous B-cell lymphomas Part I. Clinical features, diagnosis, and classification
Primary cutaneous B-cell lymphomas Part I. Clinical features, diagnosis, and classification
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DOI：
10.1016/j.jaad.2013.06.012
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发表时间：
2013-09-01
影响因子：
13.8
通讯作者：
Myskowski, Patricia L.
中科院分区：
文献类型：
--
作者：
Suarez, Andrea Luisa;Pulitzer, Melissa;Myskowski, Patricia L.
原发性皮肤B细胞淋巴瘤（PCBCL）定义为具有B细胞表型的淋巴瘤，在适当分期后，在初始表现时存在于皮肤中，没有全身性或皮外疾病的证据。在非霍奇金淋巴瘤，皮肤是第二个最常见的网站后，胃肠道淋巴结的参与。PCBCL在组织学上与其淋巴结对应物非常相似，这些组织学相似性可能导致治疗和预后的混淆。本文将总结3种主要类型的PCBCL的临床、病理和诊断特征：原发性皮肤滤泡中心淋巴瘤、原发性皮肤边缘区淋巴瘤和原发性皮肤弥漫性大B细胞淋巴瘤，腿型，以及这些实体的适当评估和分期程序。
Primary cutaneous B-cell lymphomas (PCBCLs) are defined as lymphomas with a B-cell phenotype that present in the skin without evidence of systemic or extracutaneous disease at initial presentation, after adequate staging. In non-Hodgkin lymphomas, the skin is the second most common site of extranodal involvement after the gastrointestinal tract. PCBCLs are histologically very similar to their nodal counterparts, and these histologic similarities can lead to confusion about both therapy and prognosis. This article will summarize the clinical, pathologic, and diagnostic features of the 3 main types of PCBCL: primary cutaneous follicle center lymphoma, primary cutaneous marginal zone lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg-type, and the appropriate evaluation and staging procedures for each of these entities.