Pathology of the vulnerable plaque.
Pathology of the vulnerable plaque.
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DOI：
10.1002/9780470987575.ch2
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发表时间：
2007-10
影响因子：
24
通讯作者：
R. Virmani;A. Burke;A. Farb;F. Kolodgie
中科院分区：
文献类型：
--
作者：
R. Virmani;A. Burke;A. Farb;F. Kolodgie
大多数急性冠脉综合征(ACS)患者表现为不稳定心绞痛、急性心肌梗死和冠脉猝死。冠状动脉血栓形成的最常见原因是斑块破裂和斑块侵蚀，而钙化结节则很少见。如果要发生冠状动脉疾病的进展，重要的是要认识到急性冠脉综合征的前驱病变。在这三种类型的冠状动脉血栓中，有一种是急性破裂的前驱病变。最类似于急性斑块破裂的非血栓病变是薄帽纤维动脉粥样硬化瘤(TCFA)，其特征是50年来有一个坏死的核心和覆盖着一层纤维帽，以及那些高敏C反应蛋白水平升高的患者。直到最近，人们才认识到，在活着的患者中识别它们可能有助于降低冠状动脉猝死的发生率。
The majority of patients with acute coronary syndromes (ACS) present with unstable angina, acute myocardial infarction, and sudden coronary death. The most common cause of coronary thrombosis is plaque rupture followed by plaque erosion, whereas calcified nodule is infrequent. If advances in coronary disease are to occur, it is important to recognize the precursor lesion of ACS. Of the three types of coronary thrombosis, a precursor lesion for acute rupture has been postulated. The non-thrombosed lesion that most resembles the acute plaque rupture is the thin cap fibroatheroma (TCFA), which is characterized by a necrotic core with an overlying fibrous cap measuring 50 years, and in those patients with elevated high levels of high sensitivity C-reactive protein. It has only recently been recognized that their identification in living patients might help reduce the incidence of sudden coronary death.