Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus
Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus
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来自南极真菌土曲霉的高含氧类萜
DOI：
10.1016/j.phytochem.2019.05.015
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发表时间：
2019-08-01
期刊：
影响因子：
3.8
通讯作者：
Zhang, Yonghui
中科院分区：
文献类型：
--
作者：
Feng, Wenya;Chen, Chunmei;Zhang, Yonghui
从南极真菌土曲霉中分离得到11个高氧类化合物，命名为Terreustoxins A-K及其5个类似物。通过核磁共振谱、单晶X-射线结晶学和电子捕获实验对这些未描述化合物的结构和绝对构型进行了表征。Terreustoxins A-D是Terretonins家族中具有C-6和C-7两个邻位羟基的硫代萜类化合物的第一个例子。Terreustoxin C和Terrettin在10mU M浓度下抑制ConA诱导的小鼠T细胞增殖。
Eleven highly oxygenated meroterpenoids, named terreustoxins A - K, along with five known analogues, were isolated from the Antarctic fungus Aspergillus terreus. The structures and absolute configurations of these un-described compounds were characterized by NMR spectroscopy, single-crystal X-ray crystallography, and ECD experiments. Terreustoxins A - D are the first examples of meroterpenoids with two ortho-hydroxy groups at C-6 and C-7 in the terretonins family. Terreustoxin C and terretonin inhibited the proliferation of Con A-induced murine T cells at the concentration of 10 mu M.