Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers.
Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers.
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DOI：
10.1158/1055-9965.epi-16-0496
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发表时间：
2017-03
期刊：
影响因子：
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通讯作者：
Win AK
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文献类型：
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作者：
Dashti SG;Buchanan DD;Jayasekara H;Ait Ouakrim D;Clendenning M;Rosty C;Winship IM;Macrae FA;Giles GG;Parry S;Casey G;Haile RW;Gallinger S;Le Marchand L;Thibodeau SN;Lindor NM;Newcomb PA;Potter JD;Baron JA;Hopper JL;Jenkins MA;Win AK
在DNA错配修复（MMR）基因中发生生殖系突变的人增加了结直肠癌的风险。对于这些高危人群，饮酒与结直肠癌风险之间关系的研究结果尚未得出结论。1,925名MMR基因突变携带者被招募到结肠癌家族登记处，他们完成了关于生活方式因素的问卷调查。采用加权考克斯比例风险回归模型估计饮酒与结直肠癌之间关系的风险比（HR）和95%置信区间（CI）。在769名携带者（40%）中诊断出结直肠癌，平均（标准差）年龄为42.6（10.3）岁。与戒酒相比，从任何酒精饮料中摄入乙醇高达14克/天和>28克/天与结直肠癌风险增加相关（HR，1.50; 95%CI，1.09-2.07和1.69; 95%CI，1.07-2.65; P趋势=0.05），结肠癌风险（HR，1.78; 95%CI，1.27-2.49和1.94; 95%CI，1.19-3.18; P趋势=0.02）。然而，没有明确的证据表明与直肠癌风险有关。此外，没有证据表明消费个别酒精饮料类型（啤酒，葡萄酒，烈酒）与结直肠癌，结肠癌或直肠癌风险之间存在关联。我们的数据表明，饮酒，特别是超过28克/天的乙醇（在美国约为2标准酒精饮料），与MMR基因突变携带者的结直肠癌风险增加有关。尽管这些数据表明，MMR携带者的饮酒与结直肠癌风险增加有关，但没有证据表明剂量反应，并且并非所有类型的饮酒都与风险增加有关。
People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between alcohol consumption and colorectal cancer. Colorectal cancer was diagnosed in 769 carriers (40%) at a mean (standard deviation) age of 42.6 (10.3) years. Compared with abstention, ethanol consumption from any alcoholic beverage up to 14 grams/day and >28 grams/day were associated with increased colorectal cancer risk (HR, 1.50; 95%CI, 1.09–2.07 and 1.69; 95%CI, 1.07–2.65 respectively; P-trend=0.05), and colon cancer risk (HR, 1.78; 95%CI, 1.27–2.49 and 1.94; 95%CI, 1.19–3.18 respectively; P-trend=0.02). However, there was no clear evidence for an association with rectal cancer risk. Also, there was no evidence for associations between consumption of individual alcoholic beverage types (beer, wine, spirits) and colorectal, colon, or rectal cancer risk. Our data suggests that alcohol consumption, particularly more than 28 grams/day of ethanol (~2 standard drinks of alcohol in the US), is associated with increased colorectal cancer risk for MMR gene mutation carriers. Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk.