Bone mineral density in post-menopausal female subjects is associated with serum antioxidant carotenoids
Bone mineral density in post-menopausal female subjects is associated with serum antioxidant carotenoids
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DOI：
10.1007/s00198-007-0457-2
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发表时间：
2008-02-01
影响因子：
4
通讯作者：
Yano, M.
中科院分区：
文献类型：
--
作者：
Sugiura, M.;Nakamura, M.;Yano, M.
多吃水果和蔬菜可以降低患骨质疏松症的风险。类胡萝卜素在这些食物中含量丰富。这项研究表明，骨密度与血清类胡萝卜素。研究结果表明，β-隐黄质和β-胡萝卜素可能提供有益于骨健康的绝经后女性subjects.Introduction抗氧化类胡萝卜素丰富的水果和蔬菜。最近的流行病学研究表明，大量摄入水果和蔬菜可以降低骨质疏松症的风险，但人们对骨矿物质密度（BMD）与血清类胡萝卜素的相关性知之甚少。方法共有699名在日本静冈县米卡比镇接受健康检查的受试者（男性222名，女性477名）参与了这项研究。采用双能X线骨密度仪（DXA）测量桡骨BMD。结果在男性和绝经前女性受试者中，6种血清类胡萝卜素浓度与桡骨BMD无相关性。另一方面，在绝经后女性受试者中，血清β-隐黄素和β-胡萝卜素与桡骨BMD呈弱正相关。调整混杂因素后，绝经后女性受试者血清β-隐黄素高水平组（Q2-Q4）BMD最低四分位数与最低四分位数（Q1）的比值比（OR）为0.45（95%置信区间：0.22-0.95）。然而，这种关联是不显着的摄入量进一步调整后的矿物质和维生素。结论抗氧化类胡萝卜素，特别是β-隐黄质，显着，但部分与绝经后女性受试者的径向BMD。
High intake of fruit and vegetables may reduce the risk of osteoporosis. Carotenoids exist in abundance in these foods. This study showed the association of bone mineral density with serum carotenoids. The findings suggest that beta-cryptoxanthin and beta-carotene might provide benefits to bone health in post-menopausal female subjects.Introduction Antioxidant carotenoids are abundant in fruit and vegetables. Recent epidemiological studies show that high intakes of fruit and vegetables may reduce the risk of osteoporosis, but little is known about the association of bone mineral density (BMD) with serum carotenoids.Methods A total of 699 subjects (222 males and 477 females) who had received health examinations in the town of Mikkabi, Shizuoka Prefecture, Japan, participated in the study. Radial BMD was measured using dual-energy X-ray absorptiometry (DXA). The associations of serum carotenoid concentrations with the radial BMD were evaluated cross-sectionally.Results In male and pre-menopausal female subjects, the six serum carotenoids were not associated with the radial BMD. On the other hand, in post-menopausal female subjects, serum beta-cryptoxanthin and beta-carotene were weakly but positively correlated with the radial BMD. After adjustment for confounders, the odds ratio (OR) for the lowest quartile of BMD in the high groups (Q2-Q4) of serum beta-cryptoxanthin against the lowest quartile (Q1) was 0.45 (95% confidence interval: 0.22-0.95) in post-menopausal female subjects. However, this association was not significant after further adjusting for intakes of minerals and vitamins.Conclusions Antioxidant carotenoids, especially beta-cryptoxanthin, significantly but partly associate with the radial BMD in post-menopausal female subjects.