CHLAMYDIA-PNEUMONIAE (TWAR) IN CORONARY-ARTERIES OF YOUNG-ADULTS (15-34 YEARS OLD)
CHLAMYDIA-PNEUMONIAE (TWAR) IN CORONARY-ARTERIES OF YOUNG-ADULTS (15-34 YEARS OLD)
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DOI：
10.1073/pnas.92.15.6911
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发表时间：
1995-07-18
影响因子：
11.1
通讯作者：
BENDITT, EP
中科院分区：
文献类型：
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作者：
KUO, CC;GRAYSTON, JT;BENDITT, EP
肺炎衣原体与冠状动脉、颈动脉和主动脉动脉粥样硬化的相关性已经通过血清流行病学和动脉粥样硬化中该有机体的证明被发现，没有动脉粥样硬化的人的年龄匹配的对照组织通常是不可用的。是否存在C .肺炎与早期动脉粥样硬化和动脉粥样化在年轻人比较发现在年龄和sex-matched人没有动脉粥样硬化,冠状动脉左前降枝一个样本,formalin-fixed,从49,15 - 34岁,从动脉粥样硬化的多中心研究称为Pathobiological决定因素青年(PDAY),是由免疫细胞化学检测和聚合酶链反应(PCR) C的存在,PCR检测巨细胞病毒。苏木精/ eosin-stained部分被用来确定疾病研究样本中,七个动脉样本发现动脉粥样硬化斑块,11内膜的增厚,和31没有损伤,8个样本阳性c .肺炎的免疫细胞化学(n = 7)和/或聚合酶链反应(n = 3), 7(86%)的六个粉瘤,2的11和内膜的增厚(18%),和所有的31日正常冠状样本阳性,PCR检测巨细胞病毒阳性4例，病变动脉2例，正常动脉2例。用脂肪染色检查邻近的左冠状动脉样本发现25例患者异常，但19例患者两种检查均未发现动脉粥样硬化的证据，因此，C，肺炎在动脉粥样硬化的年轻成人冠状动脉病变中发现，而在有或无其他动脉粥样硬化证据的正常冠状动脉中未发现。
An association of Chlamydia pneumoniae with atherosclerosis of coronary and carotid arteries and aorta has been found by seroepidemiology and by demonstration of the organism in atheromata, Age-matched control tissue from persons without atherosclerosis was usually not available, We studied autopsy tissue from young persons, many with no atherosclerosis, to determine whether C. pneumoniae is present in atheroma in young persons with early atherosclerosis and to compare the findings in age and sex-matched persons without atherosclerosis, A left anterior descending coronary artery sample, formalin-fixed, from 49 subjects, 15-34 years of age, from the multicenter study called Pathobiological Determinants of Atherosclerosis in Youth (PDAY), was examined by immunocytochemistry and the polymerase chain reaction (PCR) for the presence of C, pneumoniae and by PCR for cytomegalovirus. A hematoxylin/eosin-stained section was used to determine disease present in the studied sample, Seven of the artery samples were found to have atheromatous plaque, 11 had intimal thickening, and 31 had no lesions, Eight of the samples were positive for C. pneumoniae by immunocytochemistry (n = 7) and/or PCR (n = 3), Six of the 7 (86%) atheroma, 2 of the 11 (18%) with intimal thickening, and none of the 31 normal-appearing coronary samples were positive, Four were positive by PCR for cytomegalovirus, 2 from diseased arteries and 2 from normal arteries. Examination of the adjacent left coronary artery sample with a fat stain found abnormalities in 25 of the patients, but 19 still showed no evidence of atherosclerosis as a result of either examination, Thus, C, pneumoniae is found in coronary lesions in young adults with atherosclerosis but is not found in normal-appearing coronary arteries of both persons with and without other evidence of atherosclerosis.