Learning, memory and search strategies of inbred mouse strains with different visual abilities in the Barnes maze
Learning, memory and search strategies of inbred mouse strains with different visual abilities in the Barnes maze
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DOI：
10.1016/j.bbr.2010.08.030
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发表时间：
2011-01-20
影响因子：
2.7
通讯作者：
Brown, Richard E.
中科院分区：
文献类型：
--
作者：
O'Leary, Timothy P.;Savoie, Vicki;Brown, Richard E.
在由墙壁和迷宫内视觉线索包围的小直径小鼠版本的巴恩斯迷宫上，在13个近交系的雄性和雌性小鼠中评估视觉空间学习和记忆。小鼠完成获取和逆转训练以评估学习，然后进行探测测试以评估对逃逸孔的空间位置的记忆。C57 BL/6 J和CAST/EiJ品系表现出比其他品系更好的学习性能。A/J和129/SvImJ菌株表现出较差的学习性能，这可能是由于它们的低探索率。在探针测试中，没有发现菌株之间的记忆差异。在DBA/2 J和C3 H/HeJ品系中，雄性的学习成绩优于雌性，而在其他品系中没有性别差异。然而，小鼠可能没有使用视觉空间线索来定位该迷宫中的逃避孔，因为（1）所有品系主要使用非空间序列/趋触搜索策略，（2）当逃避孔位置被移动时，没有品系显示出逆转效应，以及（3）学习和记忆表现与视觉能力的测量无关。多变量和单变量方差分析表明，具有良好视觉能力的小鼠比视觉能力差的小鼠表现更好，但效应量较小。迷宫的小直径和迷宫边缘周围的墙壁的存在可能会促进小鼠的趋触性，增加非视觉搜索策略的使用，从而减少视觉对性能的影响，并降低这种迷宫设计检测视觉空间学习和记忆中的应变差异的灵敏度。这些结果表明，巴恩斯迷宫的设计对学习和记忆过程有显著的影响。(C)2010 Elsevier B. V.保留所有权利。
Visuo-spatial learning and memory were assessed in male and female mice of 13 inbred strains on a small diameter mouse version of the Barnes maze surrounded by a wall and intra-maze visual cues. Mice completed acquisition and reversal training to assess learning, followed by a probe test to assess memory for the spatial location of the escape hole. The C57BL/6J and CAST/EiJ strains showed better learning performance than the other strains. A/J and 129/SvImJ strains showed poor learning performance, which may be due to their low rates of exploration. No differences in memory were found between strains in the probe test. Males showed better learning performance than females in the DBA/2J and C3H/HeJ strains, but there were no sex differences in the other strains. However, mice may not have used visuo-spatial cues to locate the escape hole in this maze, as (1) all strains primarily used the non-spatial serial/thigmotaxic search strategy, (2) no strains showed a reversal effect when the escape hole location was moved, and (3) learning and memory performance were not correlated with measures of visual ability. Multivariate and univariate analyses of variance indicated that mice with good visual ability performed better than mice with poor visual ability, but the effect sizes were small. The small diameter of the maze and the presence of a wall around the edge of the maze may promote thigmotaxis in mice, increasing the use of a non-visual search strategy, thereby reducing the influence of vision on performance and decreasing the sensitivity of this maze design to detect strain differences in visuo-spatial learning and memory. These results indicate that the design of the Barnes maze has a significant effect on learning and memory processes. (C) 2010 Elsevier B.V. All rights reserved.