MODIFICATIONS OF THE INTERMEDIATE FILAMENT AND NUCLEAR MATRIX NETWORKS BY THE EXTRACELLULAR-MATRIX
MODIFICATIONS OF THE INTERMEDIATE FILAMENT AND NUCLEAR MATRIX NETWORKS BY THE EXTRACELLULAR-MATRIX
复制标题
DOI：
10.1016/0006-291x(91)91375-m
复制
发表时间：
1991-08-30
影响因子：
3.1
通讯作者：
COFFEY, DS
中科院分区：
文献类型：
--
作者：
GETZENBERG, RH;PIENTA, KJ;COFFEY, DS
组织基质系统是一个动态的，相互作用的结构网络，直接连接核基质，细胞骨架和细胞外基质。我们在这里报告，正常大鼠肾上皮细胞（NRK）和Kirsten-ras转化的大鼠肾细胞，与肿瘤细胞分泌的细胞外基质的相互作用，导致修改中间丝和核基质网络的蛋白质组成。正常细胞和转化细胞之间的基质网络是不同的;然而，肿瘤细胞外基质的这些改变在两种细胞类型中是相似的。这些数据代表了细胞外基质环境的修饰可以对核基质的蛋白质组成产生影响的第一份报告。
The tissue matrix system is a dynamic, interacting structural network directly linking the nuclear matrix, cytoskeleton and the extracellular matrix. We report here that interaction of normal rat kidney epithelial cells (NRK) and Kirsten-ras transformed rat kidney cells, with an extracellular matrix secreted by tumor cells, causes modifications to the protein composition of the intermediate filament and nuclear matrix networks. The matrix networks are different between normal and transformed cells; however, these alterations by the tumor extracellular matrix are similar in both cell types. These data represent the first report that modification of the extracellular matrix environment can have an effect on the protein composition of the nuclear matrix.