Frequency-domain analysis of fast oddball responses to visual stimuli: A feasibility study
Frequency-domain analysis of fast oddball responses to visual stimuli: A feasibility study
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DOI：
10.1016/j.ijpsycho.2009.04.011
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发表时间：
2009-09-01
影响因子：
3
通讯作者：
Bach, Michael
中科院分区：
文献类型：
--
作者：
Heinrich, Sven P.;Mell, Dominik;Bach, Michael
事件相关的潜在反应对奇怪的刺激，包括P300成分，已被提出作为诊断工具，以区分精神病或高级神经疾病的装病，例如在不明原因的视力丧失的情况下。对于临床应用，记录时间短，便于统计评估是非常可取的。为此，我们研究了在快速稳态状态下记录奇球响应的可行性。我们在快速奇球范式中使用了两种可能方向的光栅，刺激间隔为214 ms。一种刺激类型（频繁）连续呈现六次，之后是另一种刺激类型（不频繁）的单一呈现。实验对象关注的是罕见的刺激类型。对脑电图记录进行频域分析。所有受试者都产生了与罕见刺激处理相关的显著谐波响应，证明了该技术的可行性，与传统的慢刺激相比，该技术有可能大大减少记录时间。我们进一步发现，频率域分析所必需的低频率刺激的规律性本身并不会降低P300的反应，正如在一些关于P300作用的假设框架中所期望的那样。(c) 2009 Elsevier B.V.版权所有
Event-related potential responses to oddball stimuli, including the P300 component, have been proposed as a diagnostic tool for discerning psychiatric or higher-level neural disorders from malingering, for instance in cases of unexplained visual loss. For clinical use, short recording durations and easy statistical assessment are highly desirable. With this aim, we investigated the feasibility of recording oddball responses in a fast steady-state regime. We used gratings with two possible orientations in a rapid oddball paradigm with an interstimulus interval of 214 ms. Six consecutive presentations of one stimulus type (frequent) were followed by a single presentation of the other (infrequent) stimulus type. Subjects were attending to the rare stimulus type. The electroencephalographic recordings were analyzed in the frequency domain. All subjects produced significant harmonic responses related to the processing of the rare stimulus, demonstrating the feasibility of the technique, with the potential of reducing recording times substantially compared to conventional slow stimulation. We furthermore found that the regularity of the occurrence of infrequent stimuli, which is necessary for frequency-domain analysis, does not per se reduce the P300 responses, as would have been expected in the framework of some hypotheses regarding the role of the P300. (c) 2009 Elsevier B.V. All rights reserved.