Prevalence and Risk Factors of Anxiety and Depression in Patients with Postherpetic Neuralgia: A Retrospective Study
Prevalence and Risk Factors of Anxiety and Depression in Patients with Postherpetic Neuralgia: A Retrospective Study
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带状疱疹后神经痛患者焦虑和抑郁的患病率和危险因素：一项回顾性研究
DOI：
10.1159/000512190
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发表时间：
2020-12-16
期刊：
影响因子：
3.4
通讯作者：
Li, Xiang
中科院分区：
文献类型：
--
作者：
Du, Jingyi;Sun, Guoliang;Li, Xiang
目的：疼痛和心理障碍是带状疱疹后神经痛（PHN）患者最常见的两大症状群。本研究旨在探讨PHN患者焦虑和抑郁障碍的危险因素。研究方法：回顾性分析了中山大学附属第三医院2017 - 2019年门诊病历中PHN患者焦虑和抑郁的潜在危险因素。采用医院焦虑抑郁量表中文版评定焦虑和抑郁。患者被回顾性地分为2组- PHN伴和不伴焦虑/抑郁-并进行比较以确定不同的患者特征。结果：纳入661例PHN患者。69.0%（456/661）的PHN患者发生焦虑和抑郁，65.8%（435/661）的PHN患者发生焦虑和抑郁。单因素回归分析结果显示，女性、疼痛强度、皮疹发作时间和皮疹扩散程度与PHN患者的焦虑和抑郁显著相关。多因素分析显示，焦虑和抑郁状态与女性性别、疼痛强度和皮疹扩散程度显著相关。结论：PHN患者中存在焦虑和抑郁症状。患有PHN的女性经历剧烈疼痛并出现广泛的皮疹，患焦虑和抑郁症的风险很高。
Objectives: Pain and psychological disorders are the 2 most commonly occurring symptom clusters in patients with postherpetic neuralgia (PHN). This study aimed to investigate the risk factors for anxiety and depressive disorders in patients with PHN. Methods: Retrospectively, we examined the potential risk factors of anxiety and depression among patients with PHN from the clinic medical records of the Third Affiliated Hospital of Sun Yat-Sen University from 2017 to 2019. The Chinese version of the Hospital Anxiety and Depression Scale was used to assess anxiety and depression. Patients were retrospectively allocated to 2 groups – PHN with and without anxiety/depression – and compared to identify the differential patient characteristics. Results: Cases of 661 patients who were diagnosed with PHN were included. Anxiety and depression developed in 69.0% (456/661) and 65.8% (435/661) of the enrolled patients with PHN, respectively. Results of univariate regression analyses showed that female sex, magnitude of pain intensity, time from onset of rash and extent of spread of rashes were significantly associated with anxiety and depression in patients with PHN. Multivariate analysis revealed that both anxiety and depression states significantly correlated with female sex, magnitude of pain intensity, and extent of spread of rashes. Conclusions: Anxiety and depression were not uncommon in patients with PHN. Women with PHN who experience severe pain and develop extensive rashes have a high risk of developing anxiety and depressive disorders.