Break-induced replication: functions and molecular mechanism.
Break-induced replication: functions and molecular mechanism.
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DOI：
10.1016/j.gde.2013.05.007
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发表时间：
2013-06
影响因子：
4
通讯作者：
Ira, Grzegorz
中科院分区：
文献类型：
--
作者：
Malkova, Anna;Ira, Grzegorz
断裂诱导复制(BIR)是从噬菌体到真核生物保守的同源重组(HR)途径，用于修复只有一端的DNA断裂。BIR有助于修复断裂的复制叉子，并允许在没有端粒酶的情况下延长端粒。非等位基因BIR可能导致易位和其他染色体重排。此外，在微同源位点启动的BIR可产生拷贝数变异和复杂的染色体变化。与DNA合成相关的突变水平在BIR中显著高于正常复制。这些特征使得BIR可能成为促进基因突变的途径，这些基因变化助长了癌症的进展和进化。
Break-induced replication (BIR) is the pathway of homologous recombination (HR) conserved from phages to eukaryotes that serves to repair DNA breaks that have only one end. BIR contributes to the repair of broken replication forks and allows telomere lengthening in the absence of telomerase. Nonallelic BIR may lead to translocations and other chromosomal rearrangements. In addition, BIR initiated at sites of microhomology can generate copy-number variations and complex chromosomal changes. The level of mutagenesis associated with DNA synthesis in BIR is significantly higher than during normal replication. These features make BIR a likely pathway to promote bursts of genetic changes that fuel cancer progression and evolution.
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影响因子：
4.5
作者：
Chung WH;Zhu Z;Papusha A;Malkova A;Ira G
通讯作者：
Ira G
影响因子：
5.2
作者：
Bondurand, Nadege;Fouquet, Virginie;Pingault, Veronique
通讯作者：
Pingault, Veronique
影响因子：
11.4
作者：
ASAI, T;SOMMER, S;KOGOMA, T
通讯作者：
KOGOMA, T
DOI：
10.1016/j.mrfmmm.2008.07.013
发表时间：
2008-10-14
影响因子：
2.3
作者：
Downing, Brandon;Morgan, Rachel;Malkova, Anna
通讯作者：
Malkova, Anna
影响因子：
64.8
作者：
Berger, Michael F.;Lawrence, Michael S.;Demichelis, Francesca;Drier, Yotam;Cibulskis, Kristian;Sivachenko, Andrey Y.;Sboner, Andrea;Esgueva, Raquel;Pflueger, Dorothee;Sougnez, Carrie;Onofrio, Robert;Carter, Scott L.;Park, Kyung;Habegger, Lukas;Ambrogio, Lauren;Fennell, Timothy;Parkin, Melissa;Saksena, Gordon;Voet, Douglas;Ramos, Alex H.;Pugh, Trevor J.;Wilkinson, Jane;Fisher, Sheila;Winckler, Wendy;Mahan, Scott;Ardlie, Kristin;Baldwin, Jennifer;Simons, Jonathan W.;Kitabayashi, Naoki;MacDonald, Theresa Y.;Kantoff, Philip W.;Chin, Lynda;Gabriel, Stacey B.;Gerstein, Mark B.;Golub, Todd R.;Meyerson, Matthew;Tewari, Ashutosh;Lander, Eric S.;Getz, Gad;Rubin, Mark A.;Garraway, Levi A.
通讯作者：
Garraway, Levi A.