Direct comparison of additively manufactured porous titanium and tantalum implants towards in vivo osseointegration
Direct comparison of additively manufactured porous titanium and tantalum implants towards in vivo osseointegration
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DOI：
10.1016/j.addma.2019.04.025
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发表时间：
2019-08-01
影响因子：
11
通讯作者：
Bose, Susmita
中科院分区：
文献类型：
--
作者：
Bandyopadhyay, Amit;Mitra, Indranath;Bose, Susmita
植入物的材料特性，如体积孔隙率和纳米级表面改性已被证明可以增强体外细胞-材料相互作用和体内骨整合。多孔钽（Ta）和钛（Ti）涂层广泛用于非骨水泥型植入物，这些植入物采用不同的工艺路线制造。近年来，其中一些植入物正在使用增材制造进行制造。然而，关于增材制造的多孔Ta和Ti结构在早期骨整合方面的直接比较，知识有限。在本研究中，我们使用激光工程净成形（LENST）制造了多孔Ta和Ti6 Al 4V（Ti64）植入物，具有相似的体积分数孔隙率，以比较表面特性和材料化学对使用大鼠股骨远端模型5周和12周的体内反应的影响。我们还评估了Ti64表面改性是否可以在大鼠股骨远端模型中引起与多孔Ta相似的体内反应，持续5周和12周。对收获的种植体进行组织学分析，以确定每个骨表面的类骨质表面。采用场发射扫描电子显微镜（FESEM）对骨-种植体界面进行评估。本文提供的结果表明，多孔Ta和表面改性多孔Ti64植入物在植入后5周通过无缝骨材料互锁实现早期骨整合的性能相当。然而，在术后12周时发现多孔Ta在类骨质形成方面具有持续和延长的疗效。
Material properties of implants such as volume porosity and nanoscale surface modification have been shown to enhance cell-material interactions in vitro and osseointegration in vivo. Porous tantalum (Ta) and titanium (Ti) coatings are widely used for non-cemented implants, which are fabricated using different processing routes. In recent years, some of those implants are being manufactured using additive manufacturing. However, limited knowledge is available on direct comparison of additively manufactured porous Ta and Ti structures towards early stage osseointegration. In this study, we have fabricated porous Ta and Ti6Al4V (Ti64) implants using laser engineered net shaping (LENST) with similar volume fraction porosity to compare the influence of surface characteristics and material chemistry on in vivo response using a rat distal femur model for 5 and 12 weeks. We have also assessed whether surface modification on Ti64 can elicit similar in vivo response as porous Ta in a rat distal femur model for 5 and 12 weeks. The harvested implants were histologically analyzed for osteoid surface per bone surface. Field emission scanning electron microscopy (FESEM) was done to assess the bone-implant interface. The results presented here indicate comparable performance of porous Ta and surface modified porous Ti64 implants towards early stage osseointegration at 5 weeks post implantation through seamless bone-material interlocking. However, a continued and extended efficacy of porous Ta is found in terms of higher osteoid formation at 12 weeks post-surgery.