Why New Biology Must Be Uncovered to Advance Therapeutic Strategies for Chronic Obstructive Pulmonary Disease.
Why New Biology Must Be Uncovered to Advance Therapeutic Strategies for Chronic Obstructive Pulmonary Disease.
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DOI：
10.1152/ajplung.00367.2020
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发表时间：
2020-11
期刊：
影响因子：
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通讯作者：
Jennifer Nguyen;D. Robinson;V. Sidhaye
中科院分区：
文献类型：
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作者：
Jennifer Nguyen;D. Robinson;V. Sidhaye
慢性阻塞性肺疾病（COPD）的特点是肺泡组织破坏（肺气肿）和气道重塑（导致慢性支气管炎），导致呼吸困难。这是一个日益严重的公共卫生问题，很少有治疗方案可以逆转疾病进展或死亡率。这在一定程度上是因为目前的治疗主要集中在改善炎症途径引起的症状，而不是治愈疾病。因此，关注上游途径的新兴研究可能有利于开发有效的治疗方法，以解决疾病的根本原因。其中一些途径包括线粒体功能、细胞骨架结构和维持以及气道水合作用，这些都受到导致COPD的毒素的影响。由于慢性阻塞性肺病的复杂性和疾病发病的未知靶点，更简单的模式生物已被证明是识别疾病相关途径和靶点的有用工具。这篇综述总结了COPD的病理、目前的治疗方法和治疗发现研究，重点是上述可以推进COPD治疗前景的途径。
Chronic obstructive pulmonary disease (COPD) is characterized by the destruction of alveolar tissue (in emphysema) and airway remodeling (leading to chronic bronchitis) which cause difficulties in breathing. It is a growing public health concern with few therapeutic options that can reverse disease progression or mortality. This is in part because current treatments mainly focus on ameliorating symptoms induced by inflammatory pathways as opposed to curing disease. Hence, emerging research focused on upstream pathways are likely to be beneficial in the development of efficient therapeutics to address the root causes of disease. Some of these pathways include mitochondrial function, cytoskeletal structure and maintenance, and airway hydration, which are all affected by toxins that contribute to COPD. Because of the complexity of COPD and unknown targets for disease onset, simpler model organisms have proven to be useful tools in identifying disease-relevant pathways and targets. This review summarizes COPD pathology, current treatments, and therapeutic discovery research, with a focus on the aforementioned pathways that can advance the therapeutic landscape of COPD.