Development of quantitative computed tomography lung protocols.
Development of quantitative computed tomography lung protocols.
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DOI：
10.1097/rti.0b013e31829f6796
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发表时间：
2013-09
影响因子：
3.3
通讯作者：
Hoffman EA
中科院分区：
文献类型：
--
作者：
Newell JD Jr;Sieren J;Hoffman EA
The purpose of this paper is to review the process of developing optimal CT protocols for quantitative lung CT. This will include discussions of the following important topics; QCT derived metrics of lung disease, QCT scanning protocols and quality control and QCT image processing software. We will briefly discuss several QCT derived metrics of lung disease that have been developed for the assessment of emphysema, small airway disease and large airway disease. The CT scanning protocol is one of the most important elements of successfully performing QCT. We will provide a detailed description of the current thinking on optimizing the QCT protocol for the assessment of COPD and Asthma. Quality control of the CT images is also a very important part of the QCT process and we will discuss why it is necessary to use CT scanner test objects (phantoms) to provide frequent periodic checks on the CT scanner calibration to assure precise and accurate CT numbers are obtained. We will discuss the use of quantitative CT image processing software to segment the lung and extract the desired QCT metrics of lung disease. We will discuss the practical issues of using this software. The data obtained from the image processing software is then combined with other clinical information, health status questionnaires, pulmonary physiology and genomic data to increase our understanding of obstructive lung disease and to improve our ability to design new therapies for these diseases.
