In Situ Cross-Linkable Gelatin-CMC Hydrogels Designed for Rapid Engineering of Perfusable Vasculatures
In Situ Cross-Linkable Gelatin-CMC Hydrogels Designed for Rapid Engineering of Perfusable Vasculatures
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DOI：
10.1021/acsbiomaterials.6b00203
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发表时间：
2016-06-01
影响因子：
5.8
通讯作者：
Fukuda, Junji
中科院分区：
文献类型：
--
作者：
Kageyama, Tatsuto;Osaki, Tatsuya;Fukuda, Junji
可以在生理条件下快速交联的水凝胶有利于血管化三维（3D）组织和器官的工程化，特别是当细胞以高细胞密度包埋或组织使用自下而上的方法（包括生物打印和微成型）制造时。在这里，我们制备了明胶-羧甲基纤维素（CMC）水凝胶，快速交联（
Hydrogels that can be rapidly cross-linked under physiological conditions are beneficial for the engineering of vascularized 3-dimensional (3D) tissues and organs, in particular when cells are embedded at a high cell density or tissues are fabricated using bottom-up processes, including bioprinting and micromolding. Here, we prepared a gelatin-carboxymethylcellulose (CMC) hydrogel that cross-linked rapidly (