Codon usage bias in herpesvirus
Codon usage bias in herpesvirus
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DOI：
10.1007/s00705-010-0597-0
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发表时间：
2010-03-01
影响因子：
2.7
通讯作者：
Fu, Minghui
中科院分区：
文献类型：
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作者：
Fu, Minghui
在这项研究中，我对 43 种疱疹病毒的密码子使用偏差进行了全面分析，这些病毒的全基因组已被测序。有效密码子数的值表明，除了单纯病毒和一些水痘病毒外，大多数疱疹病毒不具有高密码子偏倚性。对应分析、密码子第三位ENC和GC含量图以及偏好密码子分析的结果均表明，密码子偏倚主要受核苷酸组成的影响。这表明突变压力是影响疱疹病毒密码子使用偏倚的主要因素。
In this study, I present a comprehensive analysis of codon usage bias in 43 herpesviruses for which the whole genome has been sequenced. The values of the effective number of codons revealed that the majority of the herpesviruses did not have high codon bias, with the exceptions of only simplexviruses and some varicelloviruses. The results of correspondence analysis, a plot of ENC and GC content at the third position of the codon and analysis of preferred codons all revealed that the codon bias was mainly influenced by nucleotide composition. This suggests that mutation pressure is the main factor influencing codon usage bias in herpesviruses.