Modulation of the oviductal environment by gametes
Modulation of the oviductal environment by gametes
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DOI：
10.1021/pr070349m
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发表时间：
2007-12-01
影响因子：
4.4
通讯作者：
Fazeli, Alireza
中科院分区：
文献类型：
--
作者：
Georgiou, A. Stephen;Snijders, Ambrosius P. L.;Fazeli, Alireza
配子识别系统的概念，提醒女性在其生殖道中的配子的存在深刻地影响了我们的理解的生理事件导致的概念和生育后代。在这里，我们表明，女性在她的道内的配子的反应，通过调节怀孕最初建立的环境。我们发现输卵管基因表达的明显改变，作为精子和卵母细胞到达输卵管的结果，这直接导致体内输卵管液组成的明显改变。这表明任一配子激活输卵管内的细胞类型特异性信号转导途径。这种配子识别系统提供了一种立即和局部控制输卵管微环境的机制，在输卵管微环境中发生精子运输、精子结合和释放、获能、卵母细胞运输、受精和早期卵裂阶段胚胎发育。这可能解释了交配后性选择的机制，有证据表明，女性生殖道可以偏向不同男性的精子，有利于更具生物吸引力的男性。此外，配子识别系统的存在解释了输卵管对精子的耐受能力，同时对病原体保持不耐受。
The notion of a gamete recognition system that alerts females to the presence of gametes in their reproductive tract profoundly influences our understanding of the physiology of events leading to conception and the bearing of offspring. Here, we show that the female responds to gametes within her tract by modulating the environment in which pregnancy is initially established. We found distinct alterations in oviductal gene expression as a result of sperm and oocyte arrival in the oviduct, which led directly to distinct alterations to the composition of oviductal fluid in vivo. This suggests that either gamete activates a cell-type-specific signal transduction pathway within the oviduct. This gamete recognition system presents a mechanism for immediate and local control of the oviductal microenvironment in which sperm transport, sperm binding and release, capacitation, transport of oocytes, fertilization, and early cleavage-stage embryonic development occur. This may explain the mechanisms involved in postcopulatory sexual selection, where there is evidence suggesting that the female reproductive tract can bias spermatozoa from different males in the favour of the more biologically attractive male. In addition, the presence of a gamete recognition system explains the oviduct's ability to tolerate spermatozoa while remaining intolerant to pathogens.