Frontal cortex projections to the amygdaloid central nucleus in the rabbit
Frontal cortex projections to the amygdaloid central nucleus in the rabbit
复制标题
DOI：
10.1016/0306-4522(85)90216-7
复制
发表时间：
1985-06
期刊：
影响因子：
3.3
通讯作者：
B. Kapp;J. Schwaber;P. A. Driscoll
中科院分区：
文献类型：
--
作者：
B. Kapp;J. Schwaber;P. A. Driscoll
最近提出的证据表明，杏仁中央核直接投射到延髓背侧的心血管/自主神经调节核团上，并且在家兔中，该核团在情绪状态下可能影响心血管活动。本研究是一系列的调查，旨在提供信息的中央核在兔子的神经支配，并描述了地形和起源额皮质预测的基础上逆行和顺行轴突运输技术的核。将辣根过氧化物酶或荧光染料Bisbenzimide或Nuclear Yellow注射到中央核中，在额叶皮质的三个区域中产生了大量的逆行标记神经元：外侧表面的岛叶皮质和半球内侧表面的区域25和32。大多数标记的神经元在岛叶皮质位于第V层的背侧和后无颗粒岛叶区域，虽然标记的神经元观察到在第V层的颗粒岛叶皮质以及在第II和III层的后无颗粒岛叶皮质。标记的神经元在25和32区位于整个所有层，这些神经元的总数是大大低于观察到的岛叶皮质。放射自显影实验中，氨基酸被注入到岛叶皮质导致在中央核内的一个密集的图案的运输标签延伸到sublenticular无名质和侧部的床核的终纹。在皮质、外侧、基底外侧和基底内侧杏仁核中也观察到标记。与岛叶皮质的投射相反，25和32区的氨基酸注射只在中央核的最吻侧区域产生相对较轻的标记;这些结果表明，岛叶皮质具有直接影响中枢核团向心血管和脑血管的投射的潜力。延髓背侧的自主调节核，因此与杏仁中央核一起，似乎是参与心血管/自主调节的前脑系统的重要组成部分。
Evidence has recently been presented which demonstrates that the amygdaloid central nucleus projects directly upon cardiovascular/autonomic regulatory nuclei of the dorsal medulla and that in the rabbit this nucleus may influence cardiovascular activity during emotional states. The present study is one of a series of investigations designed to provide information on the innervation of the central nucleus in the rabbit and describes the topography and origin of frontal cortex projections to the nucleus based upon retrograde and anterograde axonal transport techniques. Injections of horseradish peroxidase or the fluorescent dyes, Bisbenzimide or Nuclear Yellow, into the central nucleus resulted in abundant numbers of retrogradely labeled neurons in three regions of the frontal cortex: the insular cortex on the lateral surface and areas 25 and 32 on the medial surface of the hemisphere. The majority of labeled neurons in the insular cortex were located in layer V of the dorsal and posterior agranular insular regions, although labeled neurons were observed in layer V of the granular insular cortex as well as in layers II and III of the posterior agranular insular cortex. Labeled neurons in areas 25 and 32 were located throughout all layers and the total number of these neurons was substantially less than that observed in the insular cortex. Autoradiographic experiments in which amino acids were injected into the insular cortex resulted in a dense pattern of transported label within the central nucleus that extended rostrally into the sublenticular substantia innominata and lateral component of the bed nucleus of the stria terminalis. Label was also observed in the cortical, lateral, basolateral and basomedial amygdaloid nuclei. In contrast to the projections from the insular cortex, amino acid injections into areas 25 and 32 resulted in only relatively light labeling within the most rostral region of the central nucleus; otherwise the nucleus was partially encapsulated and virtually devoid of label.These results suggest that the insular cortex possesses the potential to directly influence the central nucleus projection to cardiovascular/autonomic regulatory nuclei of the dorsal medulla and thus, together with the amygdaloid central nucleus, appears to be an important component of a forebrain system involved in cardiovascular/autonomic regulation.