Adenovirus 36 and Obesity in Children and Adolescents
Adenovirus 36 and Obesity in Children and Adolescents
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DOI：
10.1542/peds.2009-3362
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发表时间：
2010-10-01
期刊：
影响因子：
8
通讯作者：
Schwimmer, Jeffrey B.
中科院分区：
文献类型：
--
作者：
Gabbert, Charles;Donohue, Michael;Schwimmer, Jeffrey B.
目的：本研究的主要目的是评估腺病毒36（AD 36）特异性抗体与儿童肥胖症之间的关系。方法：对8至18岁的儿童进行横断面研究。根据BMI百分位数将儿童分类为非肥胖（=第95百分位数）。AD 36特异性中和抗体的存在进行了评估，通过使用血清中和assay.RESULTS：共124名儿童（中位年龄：13.6岁）进行了研究。在这些儿童中，46%是非肥胖的，54%是肥胖的。AD 36阳性19例（15%）。大多数AD 36阳性的儿童都是肥胖的（19名儿童中有15名[78%]）。AD 36阳性在肥胖儿童（67名儿童中的15名[22%]）中的频率显著高于非肥胖儿童（57名儿童中的4名[7%]）（P <0.05）。在肥胖的儿童的子集中，那些谁是AD 36阳性有显着较大的人体测量，包括体重，体重指数，腰围，腰/高ratio.CONCLUSION：这些数据支持肥胖和较高的体重与中和抗体的存在AD 36在儿童中的关联。如果建立因果关系，将对儿童肥胖的预防和治疗产生重大影响。儿科2010;126：721-726
OBJECTIVE: The primary aim of this study was to assess the relationship between adenovirus 36 (AD36)-specific antibodies and obesity in children.METHODS: A cross-sectional study of children 8 to 18 years of age was performed. Children were classified according to BMI percentile as nonobese (= 95th percentile). The presence of AD36-specific neutralizing antibodies was assessed by using the serum neutralization assay.RESULTS: A total of 124 children (median age: 13.6 years) were studied. Of those children, 46% were nonobese and 54% were obese. AD36 positivity was present in 19 children (15%). The majority of children found to be AD36-positive were obese (15 [78%] of 19 children). AD36 positivity was significantly (P < .05) more frequent in obese children (15 [22%] of 67 children) than nonobese children (4 [7%] of 57 children). Among the subset of children who were obese, those who were AD36-positive had significantly larger anthropometric measures, including weight, BMI, waist circumference, and waist/height ratio.CONCLUSION: These data support an association of obesity and higher body weight with the presence of neutralizing antibodies to AD36 in children. If a cause-and-effect relationship is established, it would have considerable implications for the prevention and treatment of childhood obesity. Pediatrics 2010;126:721-726