A highly efficient synthesis of rocaglaols by a novel α-arylation of ketones
A highly efficient synthesis of rocaglaols by a novel α-arylation of ketones
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DOI：
10.1002/ejoc.200400891
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发表时间：
2005-04-29
影响因子：
2.8
通讯作者：
Thede, K
中科院分区：
文献类型：
--
作者：
Diedrichs, N;Ragot, JP;Thede, K
Rocaglaols是一种天然产物，具有广泛的生物活性。用于酮的α-芳基化的新的合成方法允许合成先前不可及的罗卡酚衍生物。关键序列由以前未报道的Suzuki型反应使用溴化甲硅烷基烯醇醚作为底物，然后由芳基化甲硅烷基烯醇醚的脱保护。((c)Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2005）。
Rocaglaols are natural products exhibiting a range of biological activities. A new synthetic method for the alpha-arylation of ketones allows for the synthesis of previously inaccessible rocaglaol derivatives. The key sequence consists of a previously unreported Suzuki type reaction using brominated silyl enol ethers as substrates followed by deprotection of the arylated silyl enol ethers. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).