The role of mucus in transport by cilia.
The role of mucus in transport by cilia.
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粘液在纤毛运输中的作用。
DOI：
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发表时间：
1970
期刊：
影响因子：
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通讯作者：
A. Nevo
中科院分区：
文献类型：
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作者：
N. Eliezer;J. Sadé;A. Silberberg;A. Nevo
呼吸上皮的纤毛黏液系统是一种主要的防御机制，它可以清除暴露在空气中的腔体表面的异物。这种作用是由纤毛跳动引起的，只有在有粘液的情况下，纤毛跳动才能转化为有效的清除。研究表明，黏液在这个系统中的作用是高度特异性的。在缺乏足够粘液的情况下，系统就会失灵，而从外部添加粘液，显然只有粘液，就能恢复正常的清理功能。这意味着，在病理情况下，清除多余的粘液失败，原因可能是粘液的特定性质的改变，负责与纤毛耦合。
The mucociliary system of respiratory epithelium performs as a major defense mechanism by clearing foreign bodies from the surface of air-exposed cavities. This action is brought about by ciliary beat, which is translated into effective clearance only in the presence of mucus. It was shown that the role of mucus in this system is highly specific. In the absence of enough mucus, the system fails and the addition of mucus, and apparently only mucus, from the outside restores normal clearing function. It is implied that in pathologic situations where clearance of excess mucus fails, the reason might be an alteration of the specific properties of mucus responsible for coupling with cilia.