'Rumours of my death may halve been greatly exaggerated':: a brief review of cell death in human intervertebral disc disease and implications for cell transplantation therapy
'Rumours of my death may halve been greatly exaggerated':: a brief review of cell death in human intervertebral disc disease and implications for cell transplantation therapy
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DOI：
10.1042/bst0350680
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发表时间：
2007-08-01
影响因子：
3.9
通讯作者：
Roberts, S.
中科院分区：
文献类型：
--
作者：
Johnson, W. E. B.;Roberts, S.
人类椎间盘的无血管性质被认为降低了常驻椎间盘细胞维持其细胞外基质的能力，使组织易于变性。也有人认为，缺乏血液供应可能会导致椎间盘细胞死亡，通过营养剥夺。因此，将新的细胞移植到椎间盘中以促进组织再生将类似于“将细胞放入棺材”，注定要失败。本文综述了人类椎间盘细胞死亡的现有证据，简要描述了用于测定这种死亡的方法，并得出结论，需要进一步分析，以确定广泛的细胞死亡是否真的是人类椎间盘的一个显著特征，以及它是否与椎间盘退变和再生策略有任何关系。
The avascular nature of the human intervertebral disc is thought to reduce the ability of resident disc cells to maintain their extracellular matrix, rendering the tissue susceptible to degeneration. It has also been suggested that the lack of a blood supply may result in disc cell death via nutrient deprivation. Therefore transplanting new cells into the disc to, promote tissue regeneration would be akin to 'putting cells in a coffin' and doomed to failure. This review considers the available evidence for cell death in the human intervertebral disc, describing briefly the methods used to assay such death, and concludes that further analysis is required to ascertain whether extensive cell death truly is a marked feature of human intervertebral discs and whether it bears any relationship to disc degeneration and hence regenerative strategies.