Suppression of T lymphocyte activity by lupeol isolated from Crataeva religiosa
Suppression of T lymphocyte activity by lupeol isolated from Crataeva religiosa
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DOI：
10.1002/ptr.1852
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发表时间：
2006-04-01
影响因子：
7.2
通讯作者：
Qazi, GN
中科院分区：
文献类型：
--
作者：
Bani, S;Kaul, A;Qazi, GN
羽扇豆醇已被证明具有抗关节炎活性，通过可能的抑制免疫系统。如在以下研究中所见，发现其抑制各种免疫因子，例如巨噬细胞的吞噬（细胞杀伤）活性、包括CD 4 +T细胞介导的细胞因子产生的T淋巴细胞活性。通过流式细胞术分析在Balb/c小鼠中进行T细胞及其细胞因子的细胞内含量的评估。以12.5-200 mg/kg p.o.抑制CD 4 + T和CD 8 + T细胞计数以及细胞因子IL-2、IFN-γ（Th 1）和IL-4（Th 2）。应用流式细胞仪微球阵列（CBA）技术同时检测多种血清细胞因子。小鼠经口LD 0> 2 g/kg体重。版权所有（c）2006约翰威利父子有限公司。
Lupeol has been shown to possess antiarthritic activity through possible suppression of the immune system. As seen in the following studies, it was found to suppress various immune factors such as the phagocytic (cell-killing) activity of macrophages, T-lymphocyte activity that included CD4+T cell mediated cytokine generation. Assessment of T cells and their intracellular content of cytokines was carried out by How cytometric analysis in Balb/c mice. Oral administration of lupeol at doses of 12.5-200 mg/kg p.o. inhibited CD4+ T and CD8+ T cell counts and cytokines IL-2, IFN-gamma (Th1) and IL-4 (Th2). Cytometric bead array (CBA) technology was applied to carry out simultaneous measurement of multiple serum cytokines. The oral LD0 in mice was more than 2 g/kg body weight. Copyright (c) 2006 John Wiley & Sons, Ltd.