Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: Similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong
Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: Similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong
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DOI：
10.1006/viro.1999.9820
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发表时间：
1999-08-15
期刊：
影响因子：
3.7
通讯作者：
Guo, YJ
中科院分区：
文献类型：
--
作者：
Xu, XY;Subbarao, K;Guo, YJ
1996年，中国从广东省暴发的一只鹅身上分离出甲型鹅/广东/1/96(H5N1)流感病毒，对该病毒的全部8个核糖核酸片段进行序列分析，发现该病毒的血凝素(HA)基因与1997年在香港分离的H5N1病毒的基因相似。然而，其余的基因与其他禽流感病毒显示出更大的相似性。值得注意的是，神经氨酸酶基因并不存在H5N1香港病毒的19个氨基酸缺失，NS基因属于等位基因B，而H5N1香港病毒的神经氨酸酶基因属于等位基因A。这些数据表明，从香港暴发的H5N1病毒的HA基因来自与A/Goose/广东/1/96病毒相似的病毒或与该鹅病原体共享一个祖先。(C)1999年学术出版社。
Analysis of the sequences of all eight RNA segments of the influenza A/Goose/Guangdong/1/96 (H5N1) virus, isolated from a sick goose during an outbreak in Guangdong Province, China, in 1996, revealed that the hemagglutinin (HA) gene of the virus was genetically similar to those of the H5N1 viruses isolated in Hong Kong in 1997. However, the remaining genes showed greater similarity to other avian influenza viruses. Notably, the neuraminidase gene did not have the 19-amino-acid deletion in the stalk region seen in the H5N1 Hong Kong viruses and the NS gene belonged to allele B, while that of the H5N1 Hong Kong viruses belonged to allele A. These data suggest that the H5N1 viruses isolated from the Hong Kong outbreaks derived their HA genes from a virus similar to the A/Goose/Guangdong/1/96 virus or shared a progenitor with this goose pathogen. (C) 1999 Academic Press.