Hemophagocytic lymphohistiocytosis associated to Haemophilus parainfluenzae endocarditis– a case report
Hemophagocytic lymphohistiocytosis associated to Haemophilus parainfluenzae endocarditis– a case report
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副流感嗜血杆菌心内膜炎相关的噬血细胞淋巴组织细胞增多症一例报告
DOI：
10.1080/17843286.2017.1341691
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发表时间：
2018
影响因子：
1.6
通讯作者：
Deborah Konopnicki
中科院分区：
文献类型：
--
作者：
D. I. C. Strachinaru;M. Chaumont;D. Gobin;L. Sattar;Mihai Strachinaru;E. Karakike;Alain Roman;Deborah Konopnicki
背景：噬血细胞性淋巴组织细胞病（HLH）是一种罕见但严重且可能致命的综合征，其特征是网状内皮系统中良性巨噬细胞增殖和活化增加，并伴有噬血细胞症。在感染（通常是病毒）、恶性肿瘤、风湿病和代谢性疾病的情况下，这种综合征可分为原发性（遗传性）或继发性。病例总结：我们报告一例HLH合并副流感嗜血杆菌二尖瓣心内膜炎，并在抗生素和手术治疗下解决。我们也回顾了其他与HLH相关的感染性心内膜炎病例报告。结论：该综合征可能未被充分诊断。据我们所知，这是首例与副流感嗜血杆菌心内膜炎相关的HLH综合征的报道。
Abstract Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe and potentially fatal syndrome that is characterized by increased proliferation and activation of benign macrophages with hemophagocytosis throughout the reticuloendothelial system. This syndrome is classified as primary (genetic) or secondary when acquired in the context of infections (usually viral), malignancies, rheumatologic and metabolic diseases. Case summary: We report a case of HLH complicating a Haemophilus parainfluenzae mitral valve endocarditis and resolving under antibiotic and surgical treatment alone. We also review other case reports of infective endocarditis associated with HLH. Conclusion: The syndrome is probably underdiagnosed. To our knowledge, this is the first report of a HLH syndrome associated with H. parainfluenzae endocarditis.