Pain-measurement tools in sickle cell disease: where are we now?
Pain-measurement tools in sickle cell disease: where are we now?
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DOI：
10.1182/asheducation-2017.1.534
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发表时间：
2017-12-01
影响因子：
3
通讯作者：
Brandow, Amanda M.
中科院分区：
文献类型：
--
作者：
Darbari, Deepika S.;Brandow, Amanda M.
疼痛是一种复杂的多维体验，也是镰状细胞病（SCD）患者最常见的疾病。评估疼痛的工具不仅可以用于指导疼痛治疗，还可以提供对潜在疼痛神经生物学的深入了解。SCD疼痛的机制是多因素的，尚未完全阐明。尽管镰状红细胞对微血管的血管闭塞被认为是急性血管闭塞性疼痛的潜在机制，但慢性疼痛的机制以及从急性疼痛向慢性疼痛的转变仍在研究中。在临床实践和/或研究中可以使用许多模态来捕获疼痛的各种维度。疼痛评估工具的选择应以评估的目的为指导。疼痛评估工具，其中许多目前处于验证的早期阶段，在这里进行了讨论。这些多模式工具的开发和验证对于提高对SCD疼痛及其管理的理解至关重要。
Pain is a complex multidimensional experience and the most common morbidity in patients with sickle cell disease (SCD). Tools to assess pain can be of use not only to guide pain treatment but also to provide insight into underlying pain neurobiology. Mechanisms of pain in SCD are multifactonal and are not completely elucidated. Although vaso-occlusion of microarculation by sickled red cells is believed to be the underlying mechanism of acute vaso-occlusive pain, mechanisms for chronic pain and the transition from acute to chronic pain are under investigation. A number of modalities can be used in clinical practice and/or research to capture various dimensions of pain. Selection of a pain assessment tool should be directed by the purpose of the assessment. Pain-assessment tools, many of which are currently in the early stages of validation, are discussed here. Development and validation of these multimodal tools is crucial for developing improved understanding of SCD pain and its management.