Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control.
Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control.
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DOI：
10.2147/rrtm.s237461
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发表时间：
2020
影响因子：
3.1
通讯作者：
Cabada MM
中科院分区：
文献类型：
--
作者：
Caravedo MA;Cabada MM
这篇评论的目的是批判性地评估目前的知识流行病学，诊断和管理的片形吸虫感染的人类。片形吸虫病是一种新出现的被忽视的人畜共患传染病，影响人类的健康和福祉。感染负担尚不清楚，研究表明，人类和牲畜片形吸虫病的地理扩展可能与气候变化有关。感染可以是无症状的或以急性或慢性形式存在。无论表现如何，片形吸虫病都可能伴有长期并发症，如贫血和营养不良。在感染早期，抗体检测是唯一可用于诊断确认的工具。在慢性形式血清学和粪便显微镜检查是有帮助的。其他测试，如抗原检测和基于PCR的方法，包括等温测试，已显示出有希望的结果。Triclabendazole是目前治疗片形吸虫感染的唯一药物。然而，家畜和人类耐药感染的报道威胁着流行地区感染的临床护理和控制。片形吸虫病是一种世界范围内新出现的感染，负担不确定。诊断测试和治疗替代方案缺乏标准化，阻碍了感染的治疗和控制。
This review aims to critically assess current knowledge about the epidemiology, diagnosis, and management of Fasciola infection in humans. Fascioliasis is an emerging neglected zoonotic infection affecting the health and wellbeing of human populations. The burden of infection is unclear, and studies have shown the geographic expansion of fascioliasis in human and livestock likely related to climate change. The infection can be asymptomatic or present in acute or chronic forms. Regardless of the presentation, fascioliasis can be associated with long-term complications such as anemia and malnutrition. Early in the infection, antibody testing is the only tool available for diagnosis confirmation. In the chronic forms serology and stool microscopy are helpful. Other tests such as antigen detection and PCR-based methods including isothermal tests have shown promising results. Triclabendazole is the only drug available to treat Fasciola infection. However, reports of resistant infections in livestock and human threaten the clinical care and control of the infection in endemic areas. Fascioliasis is an emerging infection around the world with an uncertain burden. Lack of standardization of diagnostic testing and treatment alternatives hinder treatment and control of the infection.