The thalamus as a monitor of motor outputs
The thalamus as a monitor of motor outputs
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DOI：
10.1098/rstb.2002.1171
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发表时间：
2002-12-29
影响因子：
6.3
通讯作者：
Sherman, SM
中科院分区：
文献类型：
--
作者：
Guillery, RW;Sherman, SM
许多通往丘脑的上升路径都有参与运动控制的分支。此外，最近定义的，丰富的神经支配的“高级”丘脑核（如枕）的锥体细胞在第五层的新皮层也来自分支的长下行轴突，供应运动结构。对于许多丘脑高级核团来说，要理解传递到皮层的信息，线索将取决于对这些第五层运动输出的性质的了解，以及对来自功能不同的输出类型的信息如何组合为高级皮层区域的输入的定义。目前的证据表明，许多甚至可能是所有的丘脑传递到新皮层的信息都是关于皮层和皮层下神经元对运动控制做出贡献的指令。因此，我们可以看到，大脑皮层的知觉功能代表了对正在进行的运动指令的抽象。
Many of the ascending pathways to the thalamus have branches involved in movement control. In addition, the recently defined, rich innervation of 'higher' thalamic nuclei (such as the pulvinar) from pyramidal cells in layer five of the neocortex also comes from branches of long descending axons that supply motor structures. For many higher thalamic nuclei the clue to understanding the messages that are relayed to the cortex will depend on knowing the nature of these layer five motor outputs and on defining how messages from groups of functionally distinct output types are combined as inputs to higher cortical areas. Current evidence indicates that many and possibly all thalamic relays to the neocortex are about instructions that cortical and subcortical neurons are contributing to movement control. The perceptual functions of the cortex can thus be seen to represent abstractions from ongoing motor instructions.