Carbamazepine Hypersensitivity Syndrome: Report of 4 Cases and Review of the Literature
Carbamazepine Hypersensitivity Syndrome: Report of 4 Cases and Review of the Literature
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卡马西平过敏综合征4例报告并文献复习
DOI：
10.1097/00005792-199505000-00004
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发表时间：
1995
期刊：
影响因子：
1.6
通讯作者：
Andries Louagie
中科院分区：
文献类型：
--
作者：
A. D. De Vriese;J. Philippe;D. van Renterghem;C. de Cuyper;P. Hindryckx;E. Matthys;Andries Louagie
本文报告4例服用卡马西平后发生严重全身过敏反应的患者，为证实对卡马西平的过敏反应，我们进行了斑贴试验和体外淋巴细胞转化试验。斑贴试验在患者中呈一致和强阳性，而在对照中呈阴性。4例患者中3例淋巴细胞转化试验阳性。我们回顾了卡马西平诱导的假性淋巴瘤和其他严重的全身性超敏反应的报告的文献。考虑到许多常见的临床、生化和病理特征，我们建议将这些反应归类为“卡马西平超敏反应综合征”。“该综合征的特征是在服用卡马西平后1周至3个月内出现发热、皮疹和淋巴结病。可能涉及各种其他靶器官，包括肝脏、肾脏和肺。卡马西平过敏综合征是一种临床诊断。斑贴试验和淋巴细胞转化试验是确诊的有价值的工具，但只有在所有体征消退后才可靠。其他芳香族抗惊厥药（苯妥英、其他乙内酰脲和苯巴比妥）也描述了类似的综合征，并且有证据表明卡马西平和苯妥英之间存在交叉反应。目前尚不清楚卡马西平超敏反应综合征是否应被认为是一种癌前状态，恶性淋巴瘤的发展风险增加。
We report 4 patients who developed a severe systemic hypersensitivity reaction when taking carbamazepine, To prove hypersensitivity to carbamazepine, we performed patch tests and in vitro lymphocyte transformation tests. Patch tests were uniformly and strongly positive in patients and negative in controls. Lymphocyte transformation tests were positive in 3 of 4 patients. We reviewed the literature on reports of carbamazepine-induced pseudolymphoma and other severe systemic hypersensitivity reactions. Considering the many common clinical, biochemical, and pathologic characteristics, we propose to group these reactions under the term "carbamazepine hypersensitivity syndrome." The syndrome is characterized by the development of fever, rash, and lymphadenopathy between 1 week and 3 months after the introduction of carbamazepine. A variety of other target organs may be involved, including the liver, kidneys, and lungs. The carbamazepine hypersensitivity syndrome is a clinical diagnosis. Patch tests and lymphocyte transformation tests are valuable tools to confirm the diagnosis, but are reliable only after all signs subside. Similar syndromes have been described with the other aromatic anticonvulsants (phenytoin, the other hydantoins, and phenobarbital), and there is evidence of a cross-reaction between carbamazepine and phenytoin. It is unknown whether the carbamazepine hypersensitivity syndrome should be considered a premalignant state, with an increased risk for the development of malignant lymphoma.
过敏性肺炎中支气管肺泡灌洗玻连蛋白水平升高。
DOI：
10.1164/ajrccm/147.2.332
发表时间：
1993
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Teschler,H;Pohl,WR;Thompson,AB;Konietzko,N;Mosher,DF;Costabel,U;Rennard,SI
通讯作者：
Rennard,SI
蕈样肉芽肿和皮肤病性淋巴结病中 T 细胞受体基因的克隆重排。
DOI：
10.1056/nejm198508293130903
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Weiss,LM;Hu,E;Wood,GS;Moulds,C;Cleary,ML;Warnke,R;Sklar,J
通讯作者：
Sklar,J