Cognitive Dysfunction in Patients With Late-Life Somatic Symptom Disorder: A Comparison According to Disease Severity
Cognitive Dysfunction in Patients With Late-Life Somatic Symptom Disorder: A Comparison According to Disease Severity
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DOI：
10.1016/j.psym.2014.10.004
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发表时间：
2015-09-01
期刊：
影响因子：
3.4
通讯作者：
Nakayama, Kazuhiko
中科院分区：
文献类型：
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作者：
Inamura, Keisuke;Shinagawa, Shunichiro;Nakayama, Kazuhiko
背景：晚升躯体症状障碍（SSD）以各种衰老相关因素为特征，如功能下降、心理问题和认知功能障碍。然而，认知功能障碍发生在晚期SSD的细节仍然未知。目的：本研究的目的是揭示老年SSD患者的认知状况，并评估认知功能障碍如何影响疾病严重程度。方法：将老年SSD患者（n = 40）与正常对照组（n = 21）的认知特征进行比较。此外，我们将老年SSD患者分为轻至中度组（n = 24）和重度组（n = 16），比较三组患者的认知情况。结果：老年SSD患者精神状态检查总分较低，注意力下降。在三组比较中，重度组的精神状态检查评分和额叶评估评分均低于正常对照组，轻至中度组与正常对照组比较差异无统计学意义。结论：我们的数据表明，不同的疾病严重程度可能存在不同的认知模式，可能表明发病机制的差异。
Background: Late-lift somatic symptom disorder (SSD) is characterized by various aging-associated factors, such as a,functional decline, psychosocatl problems, and cognitive dysfunction. However, the details of the cognitive dysfunction that occur in late-lift SSD are still unknown. Objective: The aims of this study were to reveal the cognitive profile of patients with late-life SSD and to evaluate how cognitive dysfunction affects disease severity. Methods: We compared the cognitive profiles of patients with late-life SSD (n = 40) with those of normal control subjects (n = 21). In addition, we divided the patients with late-life SSD into mild-to-moderate (n = 24) and severe (n = 16) groups and compared the cognitive profiles of the 3 groups. Results: Patients with late-life SSD exhibited a lower Mini-Mental State Examination total score and attention decline. In the 3-group comparison, the severe group had a lower Mini-Mental State Examination score and Frontal Assessment Battery score than the normal control group, it no significant difference was seen between the mild-to-moderate and the normal control groups. Conclusions: Our data suggest that different cognitive patterns may exist depending on disease severity, possibly indicating differences in pathogenesis.