Nanolignin-based high internal phase emulsions for efficient protection of curcumin against UV degradation
Nanolignin-based high internal phase emulsions for efficient protection of curcumin against UV degradation
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基于纳米木质素的高内相乳液，可有效保护姜黄素免受紫外线降解
DOI：
10.1016/j.ijbiomac.2022.12.123
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发表时间：
2023
影响因子：
8.2
通讯作者：
Lu Fachuang
中科院分区：
文献类型：
--
作者：
Zhang Han;Yue Fengxia;Hu Songnan;Qi Haisong;Lu Fachuang
作为乳化剂，木质素在用于药物递送的载药乳液系统上表现出优异的抗紫外线性。然而，由于来自不同来源的木质素的结构变化和复杂性，它们的UV屏蔽性能随木质素提取技术而变化，这影响了基于木质素的HIPE（高内相乳液）的性能和保护效率。在这项工作中，木质素纳米粒子，从桉树的木质素制剂制备，用于HIPES传递系统，以保护姜黄素从紫外线辐射降解。使用2D HSQC（异质单量子相干）NMR（核磁共振）、31 P NMR和GPC（凝胶渗透色谱）表征木质素制剂的结构。紫外光照射36 h后，纳米木质素基HIPE中姜黄素的残留量超过72%，远高于不含木质素的油相中姜黄素的残留量（紫外光照射24 h后，姜黄素的残留量< 10%），表明纳米木质素基HIPE具有增强的紫外光屏蔽能力，对姜黄素有更好的保护作用。在三种木质素制备物中，分子量最小、酚羟基和羧基含量最高、S/G值最大的碱木质素（AL）具有最好的抗紫外辐射能力和最均匀的纳米颗粒尺寸。
As an emulsifier, lignin exhibits excellent UV resistance on drug-loaded emulsion systems for drug delivery. However, due to the structural variation and complexity of lignins from various origins, their UV shielding performance varies with the techniques for lignin extraction, which impacts properties and the protection efficiency of lignin-based HIPEs (high internal phase emulsions). In this work, lignin nanoparticles, prepared from three lignin preparations of Eucalyptus, were used in HIPEs delivery systems to protect curcumin from degradation by UV radiation. Structures of the lignin preparations were characterized using 2D HSQC (heteronuclear single-quantum coherence) NMR (nuclear magnetic resonance), 31P NMR, and GPC (gel permeation chromatography). The residual curcumin level after 36h UV exposure in the nanolignin-based HIPEs was over 72%, much higher than that (< 10% after 24h UV exposure) in the oil phase without lignin, indicating that the nanolignin-based HIPEs with enhanced UV shielding ability protect curcumin better. Of the three lignin preparations, AL (alkali lignin), with the lowest molecular weight, highest contents of phenolic hydroxyl and carboxyl groups, and highest S/G ratio, displayed the best anti-UV radiation ability and the most uniform nanoparticle size.