No Lewy Pathology in Monkeys with Over 10 Years of Severe MPTP Parkinsonism
No Lewy Pathology in Monkeys with Over 10 Years of Severe MPTP Parkinsonism
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DOI：
10.1002/mds.22481
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发表时间：
2009-07-30
影响因子：
8.6
通讯作者：
Obeso, Jose A.
中科院分区：
文献类型：
--
作者：
Halliday, Glenda;Trinidad Herrero, Maria;Obeso, Jose A.
The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased alpha-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific. (C) 2009 Movement Disorder Society
