RELAPSE OF HERPES-SIMPLEX ENCEPHALITIS
RELAPSE OF HERPES-SIMPLEX ENCEPHALITIS
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DOI：
10.1055/s-2008-1052425
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发表时间：
1987-02-01
期刊：
影响因子：
1.4
通讯作者：
GRANGEPONTE, MC
中科院分区：
文献类型：
--
作者：
BARTHEZ, MA;BILLARD, C;GRANGEPONTE, MC
本报告描述了一个儿童单纯疱疹病毒（HSV）脑炎谁得到显着改善，而与阿昔洛韦治疗，但随后有神经功能恶化和死亡。尸检时，脑中存在严重的坏死过程，但无脱髓鞘和炎症反应不良的局灶性区域。在复发或尸检期间，未从脑活检中培养出HSV。本文回顾了十四例复发性疱疹性脑炎的病例，并讨论了复发的治疗方案和机制。
This report describes a child with herpes simplex virus (HSV) encephalitis who improved dramatically while being treated with acyclovir but subsequently had neurological deterioration and died. A severe necrotizing process was present in the brain at autopsy but there were no focal areas of demyelination and poor inflammatory response. HSV was not cultured from brain biopsy during relapse or autopsy. Fourteen previous cases of relapsing herpes encephalitis are reviewed and treatment regime and mechanisms of relapse are discussed.