Canagliflozin-induced pancreatitis: a rare side effect of a new drug.
Canagliflozin-induced pancreatitis: a rare side effect of a new drug.
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DOI：
10.2147/tcrm.s86641
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发表时间：
2015
影响因子：
2.8
通讯作者：
Chhabra A
中科院分区：
文献类型：
--
作者：
Chowdhary M;Kabbani AA;Chhabra A
急性胰腺炎最常见的原因是胆结石、酗酒和代谢紊乱，如高脂血症和高钙血症。药物是胰腺炎的一种罕见但常被忽视的病因。虽然有几种药物与此有关，但抗糖尿病药物是药物性胰腺炎的罕见原因。卡格列净是SGLT-2抑制剂类新药，用于治疗2型糖尿病。报告的严重副作用包括肾损害、高钾血症和低血压。然而，卡格列净导致的胰腺炎极为罕见。在此，我们描述了一例33岁女性病例，该患者在近期开始卡格列净治疗的情况下出现重度急性胰腺炎。考虑到她就诊的时间，在排除所有其他可能的病因后，确定卡格列净可能是她的疾病来源。该病例强调了识别药物诱导的胰腺炎的重要性，尤其是在新药中，因为它在患有多种医学合并症和服用多种药物的患者中通常被忽视。及时识别药物性胰腺炎可以改善治疗，并降低这些患者的发病率和死亡率。
Acute pancreatitis is most commonly attributed to gallstones, alcohol abuse, and metabolic disorders such as hyperlipidemia and hypercalcemia. Medications are an infrequent yet commonly overlooked etiology of pancreatitis. Although several drugs have been implicated, antidiabetic agents are a rare cause for drug-induced pancreatitis. Canagliflozin is a new drug in the class of SGLT-2 inhibitors used for the treatment of type 2 diabetes mellitus. Serious reported side effects include renal impairment, hyperkalemia, and hypotension. Pancreatitis as a result of canagliflozin, however, is exceedingly rare. Here we describe a case of a 33-year old female who presented with severe acute pancreatitis in the setting of recent initiation of canagliflozin. Given the timing of her presentation and after excluding all other possible etiologies, it was determined that canagliflozin was the likely source of her illness. This case highlights the importance of identifying drug-induced pancreatitis, especially in novel drugs, as it is commonly neglected in patients with multiple medical comorbidities and those taking numerous medications. Prompt identification of drug-induced pancreatitis can improve management as well as decrease morbidity and mortality in these individuals.