PI3K/PTEN signaling in tumorigenesis and angiogenesis
PI3K/PTEN signaling in tumorigenesis and angiogenesis
复制标题
肿瘤发生和血管生成中的 PI3K/PTEN 信号传导。
DOI：
10.1016/j.bbapap.2007.09.008
复制
发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Liu, Ling-Zhi
中科院分区：
文献类型：
--
作者：
Jiang, Bing-Hua;Liu, Ling-Zhi
磷脂酰肌醇3-激酶（PI3K）可被多种细胞外信号激活，并参与许多细胞过程，包括细胞增殖、存活、蛋白质合成和肿瘤生长。10号染色体上缺失的磷酸酶和紧张素同源物（PTEN）是PI3K的拮抗剂。PI3K通路的改变，如致癌基因的激活、基因扩增和抑癌基因的失活，在许多人类癌症中都很常见。当肿瘤直径超过1毫米时，血管生成是肿瘤生长和转移所必需的。最近的研究表明，PI3K和Akt通过VEGF和HIF-1的表达在调节肿瘤生长和血管生成中发挥重要作用。PI3K通过HDM2和p70S6K1在人类癌细胞中调控这两种蛋白的表达。人类癌症中PI3K/PTEN通路的频繁失调表明该通路是癌症治疗的合适靶点。在这篇综述中，我们介绍了PI3K/PTEN通路的最新进展，PI3K在调节肿瘤生长和血管生成中的作用和机制，以及针对该通路进行癌症治疗的潜在治疗机会。(C) 2007 Elsevier B.V.版权所有
The phosphatidyl inositol 3-kinase (PI3K) can be activated by a variety of extracellular signals and involved in a number of cellular processes including cell proliferation, survival, protein synthesis, and tumor growth. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is an antagonist of PI3K. The alterations of PI3K pathway such as activation of oncogenes, gene amplification, and inactivation of tumor suppressors, commonly occur in many human cancers. Angiogenesis is required for tumor growth and metastasis when the tumor reaches more than I mm in diameter. Recent studies have shown that PI3K and Akt play an important role in regulating tumor growth and angiogenesis through VEGF and HIF-1 expression. PI3K regulates the expression of these two proteins through HDM2 and p70S6K1 in human cancer cells. The frequent dysregulation of the PI3K/PTEN pathway in human cancer demonstrates that this pathway is an appropriate target for cancer therapeutics. In this review, we describe the recent advances in understanding the PI3K/PTEN pathway, the role and mechanism of PI3K in regulating tumor growth and angiogenesis, and the potential therapeutic opportunities for targeting this pathway for cancer treatment. (C) 2007 Elsevier B.V. All rights reserved.