Sex steroids are necessary in the second postnatal week for the expression of male alloparental behavior in prairie voles (Microtus ochragaster).
Sex steroids are necessary in the second postnatal week for the expression of male alloparental behavior in prairie voles (Microtus ochragaster).
复制标题
性类固醇对于草原田鼠（Microtus ochragaster）雄性异亲行为的表达在出生后第二周是必需的。
DOI：
10.1037/a0016927
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发表时间：
2009
影响因子：
1.9
通讯作者：
Cushing,BruceS
中科院分区：
文献类型：
--
作者：
Kramer,KristinM;Perry,AdamN;Golbin,Dina;Cushing,BruceS
性类固醇在组织男性社会行为中起着重要作用，这与低水平的亲社会行为和高水平的攻击行为有关。然而，在高度社会化的男性中，类固醇在组织行为中的作用尚不清楚。作者测试了低水平的性类固醇促进雄性草原田鼠（Microtus ochragaster）亲社会行为表达的假设，并预测抑制睾酮和雌二醇会减少自发的异源性行为。用芳香化酶抑制剂1,4,6 -雄甾烯- 3,17 -二酮（ATD）或雄激素受体阻滞剂氟他胺治疗第8-14天，可显著降低21日龄雄性异亲代行为的表达。虽然两种处理都减少了异体亲代行为并增加了幼崽定向攻击，但处理效果不同。氟他胺改变了最初的反应，增加了进入幼犬笼的潜伏期和从最初接触中撤退的可能性。接受过atd治疗的异体亲代雄性表现出嗅探、舔舐和挤在一起的潜伏期增加。结果表明，内源性类固醇在雄性亲社会行为的发展中起作用，雌激素和雄激素的作用不同。（PsycINFO数据库记录(c) 2016 APA，版权所有）
Sex steroids play a significant role in organizing male social behavior, which is associated with low levels of pro-social behavior and high levels of aggression. However, the role of steroids in organizing behavior in highly social males is unclear. The authors tested the hypothesis that low levels of sex steroids facilitate the expression of pro-social behavior in male prairie voles (Microtus ochragaster), predicting that inhibition of testosterone and estradiol would reduce spontaneous-alloparental behavior. Treatment with the aromatase inhibitor 1, 4, 6-androstatriene-3, 17-dione (ATD) or the androgen receptor blocker flutamide, days 8–14, significantly reduced the expression of alloparental behavior in 21-day old males. While both treatments reduced alloparental behavior and increased pup-directed aggression, there were differential treatment effects. Flutamide altered initial response, increasing latency to enter the pup cage and the likelihood of retreat from initial contact. ATD-treated males that were alloparental showed increases in sniffing and latencies to lick and huddle. Results indicate that endogenous steroids play a role in the development of male pro-social behavior and the effects of estrogens and androgens differ.(PsycINFO Database Record (c) 2016 APA, all rights reserved)