Epithelial-mesenchymal transitions: insights from development
Epithelial-mesenchymal transitions: insights from development
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DOI：
10.1242/dev.071209
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发表时间：
2012-10-01
期刊：
影响因子：
4.6
通讯作者：
Thiery, Jean Paul
中科院分区：
文献类型：
--
作者：
Lim, Jormay;Thiery, Jean Paul
上皮-间充质转化(EMT)是发生在胚胎发育过程中的一个关键的、进化上保守的过程，对胚胎的形成是必不可少的。这种形态转变也与癌症有关，在不同的环境中通过多种机制执行，研究表明，尽管管理EMT的分子程序仍然神秘，但它嵌入了调节规范和分化的发育程序中。正如我们在这里回顾的，从原肠形成、神经脊分层和心脏形成过程中对EMT的研究中获得的知识加深了我们对肿瘤进展和转移的理解。
Epithelial-mesenchymal transition (EMT) is a crucial, evolutionarily conserved process that occurs during development and is essential for shaping embryos. Also implicated in cancer, this morphological transition is executed through multiple mechanisms in different contexts, and studies suggest that the molecular programs governing EMT, albeit still enigmatic, are embedded within developmental programs that regulate specification and differentiation. As we review here, knowledge garnered from studies of EMT during gastrulation, neural crest delamination and heart formation have furthered our understanding of tumor progression and metastasis.