Associations of Childhood and Adolescent Depression With Adult Psychiatric and Functional Outcomes.
Associations of Childhood and Adolescent Depression With Adult Psychiatric and Functional Outcomes.
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儿童期和青少年抑郁症与成人精神病和功能结果的关联。
DOI：
10.1016/j.jaac.2020.07.895
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发表时间：
2021-05
影响因子：
13.3
通讯作者：
Shanahan L
中科院分区：
文献类型：
--
作者：
Copeland WE;Alaie I;Jonsson U;Shanahan L
抑郁症很常见，具有损害性，也是青少年疾病负担的主要原因。本研究旨在确定儿童/青少年抑郁症对广泛的长期结果的影响。该分析基于对 1,420 名参与者进行的前瞻性、代表性大烟山研究。参与者在童年时期接受了多达 8 次结构化儿童和青少年精神评估访谈（9 至 16 岁；6,674 次观察；1993 至 2000 年），以了解基于 DSM 的抑郁症、相关精神合并症和童年逆境。参与者在成年后接受了 4 次随访（19、21、25 和 30 岁；1,336 名参与者的 4,556 次观察；1999 年至 2015 年），采用结构化的青少年精神病评估访谈来了解精神病结果和功能结果。 7.7% 的参与者符合儿童/青春期抑郁症的标准。任何儿童/青少年抑郁症都与成人焦虑和非法药物障碍程度较高有关，并且还与健康状况、犯罪和社会功能恶化有关；当考虑到儿童精神疾病和逆境时，这些关联仍然存在。没有发现性别特异性模式。然而，抑郁症发生的时间很重要：青少年发病的抑郁症患者的结果比儿童发病的患者更差。整个童年和青春期的平均抑郁症状与更多不良后果相关。最后，专业心理健康服务的使用可以防止成人诊断结果。早期抑郁症，尤其是持续的儿童/青少年抑郁症状与成人功能有强烈、持久的关联。其中一些影响可能会因服务的使用而减弱。美国国家心理健康、药物滥用和儿童健康与发展研究所。这项研究使用了 25 年以上大烟山研究的数据来确定成人功能的哪些方面受到儿童/青少年抑郁症的影响。儿童抑郁症与成人焦虑和非法药物问题的风险增加有关，并损害成人的健康和社会功能。情绪持续抑郁的儿童成年后的结局最差。与此同时，儿童时期使用心理健康服务可以预防成年后的焦虑。
Depression is common, impairing, and the leading cause of disease burden in youth. This study aimed to identify the effects of childhood/adolescent depression on a broad range of longer-term outcomes. The analysis is based on the prospective, representative Great Smoky Mountains Study of 1,420 participants. Participants were assessed with the structured Child and Adolescent Psychiatric Assessment interview up to 8 times in childhood (ages 9 to 16; 6,674 observations; 1993 to 2000) for DSM-based depressive disorders, associated psychiatric comorbidities and childhood adversities. Participants were followed up 4 times in adulthood (ages 19, 21, 25, and 30; 4,556 observations of 1,336 participants; 1999 to 2015) with the structured Young Adult Psychiatric Assessment Interview for psychiatric outcomes and functional outcomes. 7.7% of participants met criteria for a depressive disorder in childhood/adolescence. Any childhood/adolescent depression was associated with higher levels of adult anxiety and illicit drug disorders and also with worse health, criminal, and social functioning; these associations persisted when childhood psychiatric comorbidities and adversities were accounted for. No sex-specific patterns were identified. However, timing of depression mattered: Individuals with adolescent-onset depression had worse outcomes than those with child-onset. Average depressive symptoms throughout childhood and adolescence was associated with more adverse outcomes. Finally, specialty mental health service use was protective against adult diagnostic outcomes. Early depression and especially persistent childhood/adolescent depressive symptoms have robust, lasting associations with adult functioning. Some of these effects may be attenuated by service use. National Institutes of Mental Health, Drug Abuse, and Child Health and Development. This study used data from the 25+ year Great Smoky Mountains Study to identify which aspects of adult functioning are affected by childhood/adolescent depression. Childhood depression was associated with increased risk for adult anxiety and illicit drug problems and compromised adult health and social functioning. Children with persistent depressed mood had the worst adult outcomes. At the same time, mental health services use within childhood was protective against adult anxiety.
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DOI：
10.1016/j.jaac.2013.09.017
发表时间：
2014-01
影响因子：
13.3
作者：
Copeland, William E.;Angold, Adrian;Shanahan, Lilly;Costello, E. Jane
通讯作者：
Costello, E. Jane
影响因子：
--
作者：
Jaffee, SR;Moffitt, TE;Martin, J
通讯作者：
Martin, J
影响因子：
17.7
作者：
Kendler, KS;Gardner, CO;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
1.9
作者：
Ascher, BH;Farmer, EMZ;Angold, A
通讯作者：
Angold, A
影响因子：
6.9
作者：
ANGOLD, A;COSTELLO, EJ
通讯作者：
COSTELLO, EJ