Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates
Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates
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DOI：
10.1039/b815963g
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Figadere, Bruno
中科院分区：
文献类型：
--
作者：
Akagah, Bernardin;Lormier, Anh Tuan;Figadere, Bruno
A study comparing the chemical oxidation of drug candidates with cell-based metabolism (liver microsomes, hepatocytes) shows that biomimetic oxidation can replace the biological approach, thus allowing access to large quantities of metabolites, which can also be used for the preparation of new products.
