Sensitivity of Influenza Rapid Diagnostic Tests to H5N1 and 2009 Pandemic H1N1 Viruses
Sensitivity of Influenza Rapid Diagnostic Tests to H5N1 and 2009 Pandemic H1N1 Viruses
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DOI：
10.1128/jcm.00439-10
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发表时间：
2010-08-01
影响因子：
9.4
通讯作者：
Kawaoka, Yoshihiro
中科院分区：
文献类型：
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作者：
Sakai-Tagawa, Yuko;Ozawa, Makoto;Kawaoka, Yoshihiro
流感的简单和快速诊断有助于在临床环境中做出治疗决定。虽然许多流感快速诊断测试（IRDTs）可用于检测季节性流感病毒感染，但它们对其他病毒（如H5N1病毒和最近出现的2009年猪源大流行（H1N1）病毒）的敏感性仍然很大程度上未知。在这里，我们检查了20种IRDT对各种流感病毒株的敏感性，包括H5N1和2009年大流行的H1N1病毒。我们的研究结果表明，猪源H1N1病毒的检测灵敏度在IRDTs之间差异很大，当病毒载量较低时，一些测试缺乏足够的灵敏度来检测感染的早期阶段。
Simple and rapid diagnosis of influenza is useful for making treatment decisions in the clinical setting. Although many influenza rapid diagnostic tests (IRDTs) are available for the detection of seasonal influenza virus infections, their sensitivity for other viruses, such as H5N1 viruses and the recently emerged swine origin pandemic (H1N1) 2009 virus, remains largely unknown. Here, we examined the sensitivity of 20 IRDTs to various influenza virus strains, including H5N1 and 2009 pandemic H1N1 viruses. Our results indicate that the detection sensitivity to swine origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.