Histopathology of Mantle Cell Lymphoma
Histopathology of Mantle Cell Lymphoma
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DOI：
10.1053/j.seminhematol.2011.03.006
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发表时间：
2011-07-01
影响因子：
3.6
通讯作者：
Klapper, Wolfram
中科院分区：
文献类型：
--
作者：
Klapper, Wolfram
套细胞淋巴瘤（MCL）是一种相对罕见的淋巴瘤，仅占所有淋巴瘤的不到10%。其形态相当均匀，但在约 10% 的病例中差异显着，这使得 MCL 的诊断对组织病理学家来说具有挑战性。该疾病的定义很大程度上受到易位 t(11;14)(q13,q32) 的发现的影响，该易位将细胞周期蛋白 D1 和免疫球蛋白重链基因并置，并且存在于绝大多数 MCL 病例中。将检测cyclin D1表达的单克隆抗体引入诊断程序大大提高了病理诊断的重复性和可靠性。然而，过去几年，组织病理学家出现了新的挑战，其中包括细胞周期蛋白 D1 阴性 MCL 病例和临床相关预后亚组的检测。塞明赫马托尔 48：148-154。 (C) 2011 Elsevier Inc. 保留所有权利。
Mantle cell lymphoma (MCL) is a relatively rare lymphoma, accounting for less than 10% only of all lymphomas. Its morphology is quite homogeneous, but it varies strikingly in about 10% of the cases, making the diagnosis of MCL challenging for histopathologists. The definition of the disease was greatly influenced by the discovery of the translocation t(11;14)(q13,q32), which juxtaposes the cyclin D1 and the immunoglobulin heavy chain genes and is present in the vast majority of MCL cases. The introduction of monoclonal antibodies for the detection of cyclin D1 expression into the diagnostic procedure substantially improved the reproducibility and reliability of the pathological diagnosis. However, new challenges for histopathologists have arisen over the last years, among which are the detection of cyclin D1-negative MCL cases and clinically relevant prognostic subgroups. Semin Hematol 48:148-154. (C) 2011 Elsevier Inc. All rights reserved.