Ovulation and Follicular Development Associated With Three Low-Dose Oral Contraceptives: A Randomized Controlled Trial
Ovulation and Follicular Development Associated With Three Low-Dose Oral Contraceptives: A Randomized Controlled Trial
复制标题
排卵和卵泡发育与三种低剂量口服避孕药相关：一项随机对照试验
作者：
D. Grimes;J. Godwin;A. Rubin;Judith A. Smith;M. Lacarra
目的：探讨多相口服避孕药（OCs）增加而不是降低功能性卵巢囊肿风险的假说。方法：在这项单中心、随机对照研究中，妇女被分配到多相避孕药、低剂量单相避孕药、高剂量单相避孕药或非甾体避孕药。40名志愿者（每人10人）被随机分配到三种不同的药丸方案或非甾体类避孕药。在6个月的治疗期间，通过阴道超声检查卵泡发育，并通过血清黄体酮水平检测排卵情况。结果：与多相片剂相比，高剂量单相片剂在一个周期内发生直径大于30 mm的卵泡结构的相对危险度（RR）为0.5（95%可信区间[CI] 0.1-1.9； P= 0.49）。低剂量单相避孕药的风险与多相避孕药相当（RR 1.3,95% CI 0.5-3.6； P= 0.56）。使用多相避孕药，超过60个周期的最大排卵率为1.7 / 100个周期（95% CI 0.0-8.9）。结论：该多相丸对卵泡发育的抑制作用与低剂量单相丸比高剂量单相丸更接近。
Objective: To address the hypothesis that multiphasic oral contraceptives (OCs) increase rather than decrease the risk of functional ovarian cysts. Methods: In this single-center, randomized controlled study, women were assigned to a multiphasic pill, a lowerdose monophasic pill, a higher-dose monophasic pill, or nonsteroidal contraception. Forty volunteers were randomized (ten each) to three different pill regimens or to nonsteroidal contraception. During 6 months of treatment, follicular development was measured by vaginal ultrasonography and ovulation was indicated by serum progesterone levels. Results: The relative risk (RR) of developing a follicular structure greater than 30 mm in diameter during a cycle with the higher-dose monophasic pill was 0.5 (95% confidence interval [CI] 0.1-1.9; P=.49) compared with the multiphasic pill. The risk with the lower-dose monophasic pill was comparable to that with the multiphasic pill (RR 1.3,95% CI 0.5-3.6; P=.56). With the multiphasic pill, the maximum ovulation rate over 60 cycles was 1.7 per 100 cycles (95% CI 0.0-8.9). Conclusion: This multiphasic pill more closely resembled the lower-dose monophasic pill than the higher-dose monophasic pill in its suppression of follicular development.