Peptides and the blood-brain barrier.
Peptides and the blood-brain barrier.
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DOI：
10.1016/j.peptides.2015.03.010
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发表时间：
2015-10
期刊：
影响因子：
3
通讯作者：
Banks WA
中科院分区：
文献类型：
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作者：
Banks WA
证明肽和调节蛋白可以穿过血脑屏障 (BBB) 是 Abba J. Kastin 博士的主要贡献之一。他是第一个提出肽可以穿过血脑屏障的人，第一个证明内源性肽可以穿过血脑屏障的人，也是第一个描述肽在血脑屏障上的可饱和运输系统的人。他的研究表明，在穿越血脑屏障时，肽和调节蛋白充当信息分子，向大脑通报周围事件。大脑到血液的通道有助于控制大脑中肽的水平，并可以在大脑到血液的方向上传递信息。他表明，肽和蛋白质的转运蛋白不是静态的，而是对发育和生理变化做出反应，并受到疾病状态的影响。因此，血脑屏障能够适应中枢神经系统的需求，但当这种适应出现问题时，血脑屏障可能会成为疾病的原因。肽和蛋白质穿过血脑屏障的机制为将这些物质或其类似物递送至大脑以治疗中枢神经系统疾病提供了机会。
The demonstration that peptides and regulatory proteins can cross the blood–brain barrier (BBB) is one of the major contributions of Dr. Abba J. Kastin. He was the first to propose that peptides could cross the BBB, the first to show that an endogenous peptide did so, and the first to describe a saturable transport system at the BBB for peptides. His work shows that in crossing the BBB, peptides and regulatory proteins act as informational molecules, informing the brain of peripheral events. Brain-to-blood passage helps to control levels of peptides with the brain and can deliver information in the brain-to-blood direction. He showed that the transporters for peptides and proteins are not static, but respond to developmental and physiological changes and are affected by disease states. As such, the BBB is adaptive to the needs of the CNS, but when that adaption goes awry, the BBB can be a cause of disease. The mechanisms by which peptides and proteins cross the BBB offer opportunities for drug delivery of these substances or their analogs to the brain in the treatment of diseases of the central nervous system.