Associations between serum isomers of perfluoroalkyl acids and metabolic syndrome in adults: Isomers of C8 Health Project in China
Associations between serum isomers of perfluoroalkyl acids and metabolic syndrome in adults: Isomers of C8 Health Project in China
复制标题
全氟烷基酸血清异构体与成人代谢综合征的关联：中国C8健康工程异构体
DOI：
10.1016/j.envres.2020.110430
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发表时间：
2020
影响因子：
8.3
通讯作者：
Zeng XW
中科院分区：
文献类型：
--
作者：
Ye WL;Chen ZX;Xie YQ;Kong ML;Li QQ;Yu S;Chu C;Dongle GH;Zeng XW
背景全氟烷基酸（PFAA）暴露与代谢紊乱有关。然而，PFAAs异构体是否与代谢综合征（MetS）仍然是未知的。ObjectivesTo explore the associations between serum PFAAs isomers and MetS.MethodsWe招募了1,501名成年人的横断面研究，“异构体的C8健康项目在中国”，调查PFAAs异构体和MetS之间的关联。共检测到20种全氟辛酸，包括全氟辛烷磺酸和全氟辛酸异构体。Logistic回归模型和限制性三次样条模型被用来评估血清PFAAs异构体暴露与MetS及其组分的关系，以及调整协变量后，MetS的患病率在我们的研究是43.0%。患有代谢综合征的参与者血清中的全氟辛烷磺酸和全氟辛酸异构体水平均高于非代谢综合征参与者（p< 0.05）。我们发现，每自然对数转换ng/mL的支链全氟辛烷磺酸（br-PFOS）（比值比（OR）= 1.18，95%置信区间（CI）：1.01，1.38））线性全氟壬酸（n-PFOA）（OR = 1.35，95% CI：1.16，1.58）和全氟-6-甲基庚酸（6 m-PFOA）（OR = 1.32，95% CI：1.11，1.57），在协变量调整后，MetS的几率较高，而全氟辛烷磺酸的线性异构体则无关联（OR = 1.09，95%CI：0.94，1.25）。我们发现了一个非线性的剂量-反应关系与“阈值”的影响，在血清中的溴-PFOS异构体与MetS，其中MetS的几率迅速增加，随着血清中的溴-PFOS异构体在低暴露（非线性= 0.030）。研究结果表明，在研究全氟辛酸异构体与人体健康的关系时，需要更多地关注剂量-反应关系的非线性。
BackgroundExposure to perfluoroalkyl acids (PFAAs) is known to be associated with metabolic disorders. However, whether PFAAs isomers are associated with metabolic syndrome (MetS) still remains unknown.ObjectivesTo explore the associations between serum PFAAs isomers and MetS.MethodsWe recruited 1,501 adults from a cross-sectional study, the “Isomers of C8 Health Project in China” to investigate the associations between PFAAs isomers and MetS. A total of 20 PFAAs including the isomers of PFOS and PFOA were detected. Logistic regression models and restricted cubic spline models were used to evaluate the relationship of serum PFAAs isomers exposure with MetS and its components as well after adjusting for covariates.ResultsThe MetS prevalence in our study was 43.0%. The serum levels of both PFOS and PFOA isomers were higher in participants with MetS than that with non-MetS (p< 0.05). We found positive associations for per natural log-transformed ng/mL of branched perfluorooctane sulfonate (br-PFOS) (odds ratio (OR) = 1.18, 95% confidence interval (CI): 1.01, 1.38)) linear perfluoronanoic acid (n-PFOA) (OR = 1.35, 95% CI: 1.16, 1.58) and perfluoro-6-methylpheptanoic acid (6 m-PFOA) (OR = 1.32, 95% CI: 1.11, 1.57) with higher odds of MetS after covariates adjustment, while null association was observed for linear isomers of PFOS (OR = 1.09, 95% CI: 0.94, 1.25). We found a nonlinear dose-response relationship with a “threshold” effect in serum br-PFOS isomers with MetS, in which the odds of MetS increased quickly with increasing serum br-PFOS isomers under low exposure (pfor nonlinearity = 0.030).ConclusionWe report new evidence of associations between PFAAs isomers and MetS and the nonlinearity of dose-response relationship with br-PFOS isomers. Our findings indicate that more attention is needed to pay on the nonlinearity of dose-response relationship when investigate the association of PFAAs isomers with human health.