The polymorphisms of 9 SNP loci on mitochondrial DNA in the Chinese Han population
The polymorphisms of 9 SNP loci on mitochondrial DNA in the Chinese Han population
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中国汉族人群线粒体DNA 9个SNP位点多态性
DOI：
10.1016/j.fsigss.2009.08.081
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Yiping Hou
中科院分区：
文献类型：
--
作者：
Xiao;Y. Ye;Ying;Jin Wu;Yiping Hou
线粒体DNA（mtDNA）单核苷酸多态性是一种潜在的分析疑难案件的标志，在法医学中具有重要的应用价值。为了增加法医学案件中的有用位点，本研究采用等位基因特异性引物延伸技术，对中国成都地区汉族人群线粒体DNA上9个SNP位点的频率进行了调查，并得到了这些位点的单倍型群。结果表明，在205名非亲属人群中，共发现32个单倍型群。结果表明，mtDNA-SNP位点分析适合法医学应用，为法医学应用提供了新的遗传标记。
The single nucleotide polymorphisms on mitochondrial DNA (mtDNA) were potential markers for analysis of difficult samples in casework and played a role on forensic science. In order to increase the useful loci which could be used in forensic casework, we investigated the frequencies of 9 SNP loci on mitochondrial DNA in the Chinese Han population in Chengdu through the allele-specific primer extension, and got the haplogroups with these loci. Our results showed there were 32 haplogroups totally among 205 non-relational persons in our population sample. The results implied that the analysis of the mtDNA-SNP loci was proved to be suitable for forensic application and provided new genetic markers for the forensic purpose.