Control of keratinocyte proliferation and differentiation by p63
Control of keratinocyte proliferation and differentiation by p63
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DOI：
10.4161/cc.6.3.3753
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发表时间：
2007-02-01
期刊：
影响因子：
4.3
通讯作者：
Khavari, Paul A.
中科院分区：
文献类型：
--
作者：
Truong, Amy B.;Khavari, Paul A.
p53家族成员p63参与分层上皮组织的发育和维持，包括表皮。越来越多的数据支持p63通过维持细胞增殖在基底角质形成细胞的再生能力中发挥作用。最近的研究进一步表明，这种调节依赖于p53活性的抑制。此外，p63似乎对表皮分化施加单独的控制，这可能涉及到IKK α和Notch等关键信号分子的控制。虽然过去十年的研究极大地扩展了我们对p63功能的了解，但关于p63如何调节表皮稳态仍有很多有待了解。未来鉴定和验证p63直接靶基因以及了解单个p63同种异构体的表达和功能对于进一步确定p63在控制角质细胞增殖和分化中的作用将是重要的。
The p53 family member p63 has been implicated in both the development and maintenance of stratified epithelial tissues, including the epidermis. Increasing data support p63 function in the regenerative capacity of basal keratinocytes by maintaining cell proliferation. Recent studies further suggest this regulation relies on inhibition of p53 activity. In addition, p63 appears to exert separate control over epidermal differentiation, which may involve control of such key signaling molecules as IKK alpha and Notch. While studies over the past decade have greatly expanded our knowledge of p63 function, much remains to be understood regarding how p63 regulates epidermal homeostasis. Future efforts to identify and validate direct p63 target genes as well as to understand the expression and function of individual p63 isoforms will be important to further define how p63 functions in the control of keratinocyte proliferation and differentiation.