New Glutamine-Containing Azaphilone Alkaloids from Deep-Sea-Derived Fungus Chaetomium globosum HDN151398
New Glutamine-Containing Azaphilone Alkaloids from Deep-Sea-Derived Fungus Chaetomium globosum HDN151398
复制标题
来自深海真菌球毛壳菌 HDN151398 的新型含谷氨酰胺阿扎菲酮生物碱
DOI：
10.3390/md17050253
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发表时间：
2019-05-01
期刊：
影响因子：
5.4
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Sun, Chunxiao;Ge, Xueping;Li, Dehai
从中国南海深海沉积物中分离到的球毛壳菌（Chaetomium globosum HDN 151398）的提取物中分离得到3个新的含谷氨酰胺基的氮杂菲隆生物碱，即N-戊二酰毛壳绿素（N-glutarylchaetoviridins A-C，1-3），以及2个相关化合物（4和5）。它们的结构被阐明的基础上广泛的1D和2D NMR以及HRESIMS光谱数据和化学分析。N-戊二酰毛绿素A-C（1-3）代表以嵌入的谷氨酸残基为特征的第一类毛绿素。氨基酸孵育实验产生了5个负载不同氨基酸残基（6-10）的azaphilone，这表明该方法可以通过与氨基酸一起培养来增强该菌株的结构多样性。针对一组人癌细胞系评价分离的化合物的细胞毒性。
Three new azaphilone alkaloids containing glutamine residues, namely N-glutarylchaetoviridins A-C (1-3), together with two related compounds (4 and 5) were isolated from the extract of Chaetomium globosum HDN151398, a fungus isolated from a deep-sea sediment sample collected in South China Sea. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESIMS spectroscopic data and chemical analysis. N-glutarylchaetoviridins A-C (1-3) represent the first class of chaetoviridins characterized by embedded glutamate residues. Amino acids incubation experiments produced five azaphilone laden different amino acids residues (6-10) which indicated that this method can enhanced the structural diversity of this strain by culturing with amino acids. Cytotoxicity of the isolated compounds were evaluated against a panel of human cancer cell lines.