The role of small molecules in musculoskeletal regeneration.
The role of small molecules in musculoskeletal regeneration.
复制标题
DOI：
10.2217/rme.12.33
复制
发表时间：
2012-07
影响因子：
2.7
通讯作者：
Laurencin CT
中科院分区：
文献类型：
--
作者：
Lo KW;Ashe KM;Kan HM;Laurencin CT
骨形态发生蛋白和甲状旁腺激素疗法的使用充满了几个基本问题，例如成本、蛋白质稳定性、免疫原性、污染和超生理剂量。这些缺点可能会有效地限制其更普遍的使用。因此，显然需要替代形式的生物因子来消除基于蛋白质的诱导因子用于骨修复和再生的缺点。我们的小组研究了具有调节成骨细胞分化和矿化能力的小分子，因为它们固有的物理特性最大限度地减少了蛋白质生长因子中观察到的限制。例如，一般来说，小分子诱导剂通常更稳定、高度可溶、非免疫原性、更便宜并且需要更低的剂量。具有诱导成骨细胞分化能力的小分子可能代表下一代骨再生医学。这篇综述描述了开发基于小分子的诱导生物因子的努力，特别关注它们在骨再生中的新作用。
The uses of bone morphogenetic proteins and parathyroid hormone therapeutics are fraught with several fundamental problems, such as cost, protein stability, immunogenicity, contamination and supraphysiological dosage. These downsides may effectively limit their more universal use. Therefore, there is a clear need for alternative forms of biofactors to obviate the drawbacks of protein-based inductive factors for bone repair and regeneration. Our group has studied small molecules with the capacity to regulate osteoblast differentiation and mineralization because their inherent physical properties minimize limitations observed in protein growth factors. For instance, in general, small molecule inducers are usually more stable, highly soluble, nonimmunogenic, more affordable and require lower dosages. Small molecules with the ability to induce osteoblastic differentiation may represent the next generation of bone regenerative medicine. This review describes efforts to develop small molecule-based biofactors for induction, paying specific attention to their novel roles in bone regeneration.